C-X3-C motif chemokine ligand 1 (Q2743450)

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mammalian protein found in Homo sapiens

C-X3-C motif chemokine 1
small-inducible cytokine D1
Neurotactin
chemokine (C-X3-C motif) ligand 1
small inducible cytokine subfamily D (Cys-X3-Cys), member-1
CX3CL1
small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin)
CX3C membrane-anchored chemokine
fractalkine

Language	Label	Description	Also known as
English	C-X3-C motif chemokine ligand 1	mammalian protein found in Homo sapiens	C-X3-C motif chemokine 1 small-inducible cytokine D1 Neurotactin chemokine (C-X3-C motif) ligand 1 small inducible cytokine subfamily D (Cys-X3-Cys), member-1 CX3CL1 small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin) CX3C membrane-anchored chemokine fractalkine

Statements

1 reference

13 November 2019

UniProt protein ID

Chemokine interleukin-8-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P78423

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P78423

Chemokine interleukin-8-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

CX3C chemokine domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

cytokine activity

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

chemokine activity

determination method

4 references

1 January 2018

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

1 January 2018

Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

protein binding

determination method

4 references

1 January 2018

Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

1 January 2018

Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

1 January 2018

Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

1 January 2018

The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

CCR chemokine receptor binding

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

signaling receptor binding

determination method

1 reference

1 January 2018

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

integrin binding

determination method

1 reference

1 January 2018

Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

CX3C chemokine receptor binding

determination method

1 reference

1 January 2018

Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

integral component of membrane

determination method

3 references

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

1 January 2018

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

extracellular region

determination method

3 references

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

1 January 2018

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

biological process

G protein-coupled receptor signaling pathway

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

defense response

determination method

1 reference

1 January 2018

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

positive regulation of inflammatory response

determination method

1 reference

1 January 2018

Fractalkine is expressed by smooth muscle cells in response to IFN-gamma and TNF-alpha and is modulated by metalloproteinase activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

monocyte chemotaxis

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

cytokine-mediated signaling pathway

determination method

3 references

1 January 2018

Fractalkine is expressed by smooth muscle cells in response to IFN-gamma and TNF-alpha and is modulated by metalloproteinase activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

chemokine-mediated signaling pathway

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

angiogenesis involved in wound healing

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

cellular response to tumor necrosis factor

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

leukocyte chemotaxis

determination method

1 reference

1 January 2018

Fractalkine is expressed by smooth muscle cells in response to IFN-gamma and TNF-alpha and is modulated by metalloproteinase activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

positive regulation of angiogenesis

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

positive regulation of transforming growth factor beta1 production

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

positive regulation of GTPase activity

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

cellular response to interleukin-1

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

positive regulation of ERK1 and ERK2 cascade

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

cellular response to interferon-gamma

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

cell chemotaxis

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

positive regulation of calcium-independent cell-cell adhesion

determination method

1 reference

1 January 2018

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

determination method

3 references

1 January 2018

Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

1 January 2018

Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

integrin activation

determination method

1 reference

1 January 2018

Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

negative regulation of cell migration

determination method

1 reference

1 January 2018

MicroRNA-29b regulates migration in oral squamous cell carcinoma and its clinical significance

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

leukocyte migration involved in inflammatory response

determination method

1 reference

1 January 2018

Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

macrophage chemotaxis

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

regulation of signaling receptor activity

determination method

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78423&geneProductId=UniProtKB:P78423

determination method

Gene Atlas image

PBB GE CX3CL1 823 at fs.png
732 × 530; 11 KB

0 references

Chemokine interleukin-8-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P78423

CX3C chemokine domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P78423

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000006053

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000006053

ENSP00000456830

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000456830

ENSP00000457996

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000457996

ENSP00000464114

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464114

1 reference

Freebase Data Dumps

publication date

28 October 2013

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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