Guarding the 'translation apparatus': defective ribosome biogenesis and the p53 signaling pathway (Q27022918)

Tamayo Uechi

series ordinal

2

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Naoya Kenmochi

series ordinal

3

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language of work or name

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2011

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Wiley interdisciplinary reviews. RNA

published in

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volume

2

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issue

4

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page(s)

507-22

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The Structure and Function of Eukaryotic Ribosomes

cites work

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The economics of ribosome biosynthesis in yeast

21 January 2018

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Regulation of ribosome biogenesis within the nucleolus

21 January 2018

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Pre-ribosomes on the road from the nucleolus to the cytoplasm

21 January 2018

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5 S rRNA: structure and interactions

21 January 2018

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Recent mechanistic insights into eukaryotic ribosomes

21 January 2018

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Maturation of eukaryotic ribosomes: acquisition of functionality

21 January 2018

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Growth control and ribosome biogenesis.

21 January 2018

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Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6

21 January 2018

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Nucleolus, ribosomes, and cancer

21 January 2018

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Does the ribosome translate cancer?

21 January 2018

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Ribosomopathies: human disorders of ribosome dysfunction

21 January 2018

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When ribosomes go bad: diseases of ribosome biogenesis

21 January 2018

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Ribosomes and marrow failure: coincidental association or molecular paradigm?

21 January 2018

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How common are extraribosomal functions of ribosomal proteins?

21 January 2018

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Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway.

21 January 2018

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Live or let die: the cell's response to p53

21 January 2018

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Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

21 January 2018

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Regulation and function of the p53-related proteins: same family, different rules

21 January 2018

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Blinded by the Light: The Growing Complexity of p53

21 January 2018

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21 January 2018

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Modulation of microRNA processing by p53

21 January 2018

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Regulation and function of the p53 tumor suppressor protein

21 January 2018

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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

21 January 2018

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The p53-mdm-2 autoregulatory feedback loop

21 January 2018

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21 January 2018

Surfing the p53 network

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Regulation of HDM2 activity by the ribosomal protein L11

21 January 2018

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Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway

21 January 2018

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Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

21 January 2018

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Inhibition of HDM2 and activation of p53 by ribosomal protein L23

21 January 2018

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Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5

21 January 2018

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The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

21 January 2018

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Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function

21 January 2018

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MDMX regulation of p53 response to ribosomal stress

21 January 2018

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Putting a finger on growth surveillance: insight into MDM2 zinc finger-ribosomal protein interactions.

21 January 2018

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Signaling to p53: ribosomal proteins find their way.

21 January 2018

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Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway

21 January 2018

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Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

21 January 2018

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Ribosomal protein S7 is both a regulator and a substrate of MDM2

21 January 2018

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Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin

21 January 2018

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Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26

21 January 2018

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Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain

21 January 2018

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Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation

21 January 2018

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The role of human ribosomal proteins in the maturation of rRNA and ribosome production

21 January 2018

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Analysis of nucleolar protein dynamics reveals the nuclear degradation of ribosomal proteins

21 January 2018

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MYC as a regulator of ribosome biogenesis and protein synthesis

21 January 2018

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c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription.

21 January 2018

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c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

21 January 2018

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N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis

21 January 2018

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Direct activation of RNA polymerase III transcription by c-Myc

21 January 2018

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MYC oncogenes and human neoplastic disease

21 January 2018

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Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product

21 January 2018

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Repression of RNA polymerase I transcription by the tumor suppressor p53

21 January 2018

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p53 is a general repressor of RNA polymerase III transcription

21 January 2018

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Overlapping functions of the pRb family in the regulation of rRNA synthesis

21 January 2018

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The retinoblastoma tumour suppressor in development and cancer

21 January 2018

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Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition

21 January 2018

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Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

21 January 2018

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Nucleolin inhibits Hdm2 by multiple pathways leading to p53 stabilization.

21 January 2018

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Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation

21 January 2018

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Perturbation of rRNA synthesis in the bap28 mutation leads to apoptosis mediated by p53 in the zebrafish central nervous system

21 January 2018

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The primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress-response pathway

21 January 2018

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WDR55 is a nucleolar modulator of ribosomal RNA synthesis, cell cycle progression, and teleost organ development

21 January 2018

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Defects in 18 S or 28 S rRNA processing activate the p53 pathway

21 January 2018

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Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation.

21 January 2018

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Depletion of the nucleolar protein nucleostemin causes G1 cell cycle arrest via the p53 pathway

21 January 2018

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Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2

21 January 2018

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Inhibition of c-Myc activity by ribosomal protein L11

21 January 2018

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Loss of ribosomal protein L11 affects zebrafish embryonic development through a p53-dependent apoptotic response

21 January 2018

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Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction

21 January 2018

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Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation

21 January 2018

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Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response.

21 January 2018

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Silencing of ribosomal protein S9 elicits a multitude of cellular responses inhibiting the growth of cancer cells subsequent to p53 activation.

21 January 2018

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Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family

21 January 2018

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Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects

21 January 2018

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Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint

21 January 2018

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The p53 tumor suppressor causes congenital malformations in Rpl24-deficient mice and promotes their survival.

21 January 2018

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The ribosomal protein genes and Minute loci of Drosophila melanogaster

21 January 2018

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Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway

21 January 2018

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Identification of 315 genes essential for early zebrafish development

21 January 2018

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Ribosomal protein gene knockdown causes developmental defects in zebrafish

21 January 2018

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Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish

21 January 2018

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Many ribosomal protein genes are cancer genes in zebrafish

21 January 2018

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Deficiency of ribosomal protein S19 during early embryogenesis leads to reduction of erythrocytes in a zebrafish model of Diamond-Blackfan anemia

21 January 2018

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Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute

21 January 2018

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Global growth deficiencies in mice lacking the ribosomal protein HIP/RPL29

21 January 2018

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Ribosomal proteins and colorectal cancer

21 January 2018

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A pathogenic dyskerin mutation impairs proliferation and activates a DNA damage response independent of telomere length in mice

21 January 2018

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Deregulation of oncogene-induced senescence and p53 translational control in X-linked dyskeratosis congenita

21 January 2018

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Dyskeratosis Congenita: a historical perspective

21 January 2018

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Treacher Collins syndrome: current evaluation, treatment, and future directions

21 January 2018

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Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function.

21 January 2018

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The gene encoding ribosomal protein S19 is mutated in Diamond-Blackfan anaemia

21 January 2018

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Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients

21 January 2018

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Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia

21 January 2018

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Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia

21 January 2018

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Ribosomal protein S24 gene is mutated in Diamond-Blackfan anemia

21 January 2018

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Ribosomal protein S17 gene (RPS17) is mutated in Diamond-Blackfan anemia

21 January 2018

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Distinct haematological disorder with deletion of long arm of no. 5 chromosome

21 January 2018

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Patients with del(5q) MDS who fail to achieve sustained erythroid or cytogenetic remission after treatment with lenalidomide have an increased risk for clonal evolution and AML progression

21 January 2018

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Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

21 January 2018

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A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome

21 January 2018

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Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification

21 January 2018

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X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions

21 January 2018

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Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita

21 January 2018

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Telomere maintenance and human bone marrow failure

21 January 2018

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Novel dyskerin-mediated mechanism of p53 inactivation through defective mRNA translation

21 January 2018

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The Treacher Collins syndrome (TCOF1) gene product is involved in ribosomal DNA gene transcription by interacting with upstream binding factor

21 January 2018

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The Treacher Collins syndrome (TCOF1) gene product is involved in pre-rRNA methylation

21 January 2018

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Tcof1/Treacle is required for neural crest cell formation and proliferation deficiencies that cause craniofacial abnormalities

21 January 2018

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Diamond Blackfan anemia 2008-2009: broadening the scope of ribosome biogenesis disorders

21 January 2018

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Diamond-Blackfan anemia: diagnosis, treatment, and molecular pathogenesis

21 January 2018

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Diamond-Blackfan anemia: a ribosomal puzzle

21 January 2018

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Cells depleted for RPS19, a protein associated with Diamond Blackfan Anemia, show defects in 18S ribosomal RNA synthesis and small ribosomal subunit production.

21 January 2018

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Mutation of ribosomal protein RPS24 in Diamond-Blackfan anemia results in a ribosome biogenesis disorder

21 January 2018

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Human RPS19, the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits

21 January 2018

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Deficient RPS19 protein production induces cell cycle arrest in erythroid progenitor cells.

21 January 2018

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Ribosomal protein S19 deficiency leads to reduced proliferation and increased apoptosis but does not affect terminal erythroid differentiation in a cell line model of Diamond-Blackfan anemia.

21 January 2018

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Targeted disruption of the ribosomal protein S19 gene is lethal prior to implantation

21 January 2018

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Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype

21 January 2018

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Diamond Blackfan anemia: a disorder of red blood cell development

21 January 2018

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PIM1 kinase is destabilized by ribosomal stress causing inhibition of cell cycle progression

21 January 2018

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Repression of RNA polymerase III transcription by the retinoblastoma protein

21 January 2018

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