CD2 molecule (Q2630678)

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mammalian protein found in Homo sapiens

CD2 antigen (p50), sheep red blood cell receptor
T-cell surface antigen CD2
LFA-2
T-cell surface antigen T11/Leu-5
erythrocyte receptor
LFA-3 receptor
CD2
rosette receptor
lymphocyte-function antigen-2

Language	Label	Description	Also known as
English	CD2 molecule	mammalian protein found in Homo sapiens	CD2 antigen (p50), sheep red blood cell receptor T-cell surface antigen CD2 LFA-2 T-cell surface antigen T11/Leu-5 erythrocyte receptor LFA-3 receptor CD2 rosette receptor lymphocyte-function antigen-2

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein homodimerization activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

protein binding

determination method

7 references

8 April 2019

Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

8 April 2019

Conformation and function of the N-linked glycan in the adhesion domain of human CD2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

8 April 2019

Direct measurements of heterotypic adhesion between the cell surface proteins CD2 and CD48

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

8 April 2019

Association of CD2 and CD45 on human T lymphocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

8 April 2019

Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

8 April 2019

Multimeric and differential binding of CIN85/CD2AP with two atypical proline-rich sequences from CD2 and Cbl-b*

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

8 April 2019

Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

signaling receptor binding

determination method

1 reference

8 April 2019

The contribution of conformational adjustments and long-range electrostatic forces to the CD2/CD58 interaction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

signaling receptor activity

determination method

1 reference

8 April 2019

Conformation and function of the N-linked glycan in the adhesion domain of human CD2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

antigen binding

determination method

1 reference

21 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06729&geneProductId=UniProtKB:P06729

determination method

protein kinase binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

receptor tyrosine kinase binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

protein self-association

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

cell-cell junction

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

anchored component of plasma membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

integral component of plasma membrane

determination method

1 reference

8 April 2019

Conformation and function of the N-linked glycan in the adhesion domain of human CD2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

extracellular region

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

determination method

1 reference

7 November 2018

A novel, rapid and sensitive heterotypic cell adhesion assay for CD2-CD58 interaction, and its application for testing inhibitory peptides

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06729&geneProductId=UniProtKB:P06729

determination method

cytoplasmic side of plasma membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

plasma membrane

determination method

2 references

protein-containing complex

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

external side of plasma membrane

determination method

1 reference

7 November 2018

The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06729&geneProductId=UniProtKB:P06729

determination method

biological process

positive regulation of myeloid dendritic cell activation

determination method

1 reference

8 April 2019

CD2 engagement induces dendritic cell activation: implications for immune surveillance and T-cell activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

heterotypic cell-cell adhesion

determination method

1 reference

8 April 2019

A novel, rapid and sensitive heterotypic cell adhesion assay for CD2-CD58 interaction, and its application for testing inhibitory peptides

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

natural killer cell activation

determination method

1 reference

8 April 2019

CD2 engagement induces dendritic cell activation: implications for immune surveillance and T-cell activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

cell surface receptor signaling pathway

determination method

1 reference

8 April 2019

MHC class I cross-talk with CD2 and CD28 induces specific intracellular signalling and leads to growth retardation and apoptosis via a p56(lck)-dependent mechanism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

positive regulation of tumor necrosis factor production

determination method

1 reference

8 April 2019

Human intestinal intraepithelial lymphocytes and epithelial cells coinduce interleukin-8 production through the CD2-CD58 interaction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

T cell activation

determination method

1 reference

7 November 2018

Structure and function of the erythrocyte receptor CD2 on human T lymphocytes: a review

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06729&geneProductId=UniProtKB:P06729

determination method

leukocyte migration

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

regulation of T cell differentiation

determination method

1 reference

8 April 2019

Differentiation of regulatory T cells 1 is induced by CD2 costimulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06729

determination method

cell-cell adhesion

determination method

1 reference

7 November 2018

Conformation and function of the N-linked glycan in the adhesion domain of human CD2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06729&geneProductId=UniProtKB:P06729

determination method

Gene Atlas image

PBB GE CD2 205831 at fs.png
732 × 530; 10 KB

0 references

Immunoglobulin C2-set

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P06729

immunoglobulin V-set domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P06729

Identifiers

MeSH descriptor ID

subject named as

CD2 Antigens

0 references

D23.050.301.264.894.090

0 references

D23.101.100.894.090

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000358490

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000358490

ENSP00000358489

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000358489

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

0 references

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(16 entries)

cawiki CD2
cywiki CD2
dewiki CD2
enwiki CD2
eswiki CD2
frwiki CD2
glwiki CD2
itwiki CD2
kowiki CD2
plwiki CD2
ptwiki CD2
ruwiki CD2
trwiki CD2
ttwiki CD2
ukwiki CD2
zhwiki CD2

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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