Grapefruit juice-drug interactions (Q24683430)

British Journal of Clinical Pharmacology

Europe PubMed Central

title

Grapefruit juice-drug interactions (English)

0 references

4

J D Spence

0 references

author name string

D G Bailey

series ordinal

1

0 references

J Malcolm

series ordinal

2

0 references

O Arnold

series ordinal

3

0 references

language of work or name

English

0 references

publication date

August 1998

0 references

published in

0 references

volume

46

0 references

page(s)

101-10

0 references

issue

2

0 references

cites work

Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Relationship between time of intake of grapefruit juice and its effect on pharmacokinetics and pharmacodynamics of felodipine in healthy subjects

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Torsades de pointes after terfenadine-itraconazole interaction

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

The fate of naringin in humans: a key to grapefruit juice-drug interactions?

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Torsades de pointes occurring in association with terfenadine use

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Torsades de Pointes after treatment with terfenadine and ketoconazole

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Quercetin, an in vitro inhibitor of CYP3A, does not contribute to the interaction between nifedipine and grapefruit juice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Trough concentrations of cyclosporine in blood following administration with grapefruit juice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Effects of grapefruit juice ingestion--pharmacokinetics and haemodynamics of intravenously and orally administered felodipine in healthy men.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Cisapride. Drug interactions of clinical significance

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Factors affecting the absolute bioavailability of nifedipine

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Catalytic selectivity of human cytochrome P450 enzymes: relevance to drug metabolism and toxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Syncope and cardiac arrhythmia due to an interaction between itraconazole and terfenadine.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Grapefruit juice and drugs. How significant is the interaction?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Nifedipine. Dose-related increase in mortality in patients with coronary heart disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Pharmacokinetics of calcium antagonists under development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Astemizole: a long-acting, nonsedating antihistamine

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Cardiotoxic effect with convulsions in terfenadine overdose

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

A population study of the pharmacokinetics of felodipine

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Rhabdomyolysis associated with lovastatin and erythromycin use.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Interaction of citrus juices with felodipine and nifedipine

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

The flavonoids. A class of semi-essential food components: their role in human nutrition

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Effects of terfenadine and its metabolites on a delayed rectifier K+ channel cloned from human heart

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Combined use of astemizole and ketoconazole resulting in torsade de pointes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Effect of grapefruit juice on the pharmacokinetics of amlodipine in healthy volunteers

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

First-pass metabolism of midazolam by the human intestine.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Grapefruit juice-felodipine interaction: reproducibility and characterization with the extended release drug formulation.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Risk of developing life-threatening ventricular arrhythmia associated with tefenadine in comparison with over-the-counter antihistamines, ibuprofen and clemastine

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Torsades de pointes induced by erythromycin and terfenadine

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Torsade de pointes induced by terfenadine in a patient with long QT syndrome

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Torsades de pointes associated with terfenadine in a case of liver cirrhosis and hepatocellular carcinoma

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Felodipine kinetics in healthy men.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Myolysis and acute renal failure in a heart-transplant recipient receiving lovastatin

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Ethanol enhances the hemodynamic effects of felodipine.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 IIIA4.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Rhabdomyolysis and simvastatin

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Stereoselective inhibition of thromboxane-induced coronary vasoconstriction by 1,4-dihydropyridine calcium channel antagonists

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Grapefruit juice and cimetidine inhibit stereoselective metabolism of nitrendipine in humans

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Acute effects of drinking grapefruit juice on the pharmacokinetics and dynamics of felodipine--and its potential clinical relevance

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Can grapefruit juice influence ethinylestradiol bioavailability?

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers

19 June 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.1998.00764.X

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.1998.00764.X

Interaction between grapefruit juice and midazolam in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.1998.00764.X

Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.1998.00764.X

Influence of chronic ingestion of grapefruit juice on steady-state blood concentrations of cyclosporine A in renal transplant patients with stable graft function

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.1998.00764.X

Nifedipine in ischemic heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.1998.00764.X

Calcium antagonists in coronary artery disease and hypertension. Time for reevaluation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.1998.00764.X

Grapefruit juice and saquinavir

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873672

Grapefruit juice: a possible source of variability in blood concentration of cyclosporin A

28 November 2018

1 reference

12 December 2020

Mechanism of the cardiotoxic actions of terfenadine

1 reference

12 December 2020

Torsades de pointes occurring in association with terfenadine use

1 reference

12 December 2020

Drug interactions with grapefruit: whose responsibility is it to warn the public?

1 reference

12 December 2020

Biotransformation of lovastatin. IV. Identification of cytochrome P450 3A proteins as the major enzymes responsible for the oxidative metabolism of lovastatin in rat and human liver microsomes

1 reference

12 December 2020

Pharmacokinetics and biotransformation studies of terfenadine in man

1 reference

12 December 2020

Drug interactions, cardiac toxicity, and terfenadine: from bench to clinic?

1 reference

12 December 2020

Influence of grapefruit juice on the pharmacokinetics of a slow release nifedipine formulation

1 reference

12 December 2020

Effect of grapefruit juice on cyclosporine pharmacokinetics in renal transplant patients

1 reference

12 December 2020

Grapefruit juice--felodipine interaction: mechanism, predictability, and effect of naringin

1 reference

12 December 2020

Grapefruit juice alters terfenadine pharmacokinetics, resulting in prolongation of repolarization on the electrocardiogram

1 reference

12 December 2020

Intraoperative rhabdomyolysis in a patient receiving pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitor

1 reference

12 December 2020

Grapefruit juice-terfenadine single-dose interaction: magnitude, mechanism, and relevance

1 reference

12 December 2020

Cisapride and fatal arrhythmia

1 reference

12 December 2020

Effect of grapefruit juice on blood cyclosporin concentration

1 reference

12 December 2020

Plasma concentration-effect relationships of intravenous and extended-release oral felodipine in hypertensive patients

1 reference

12 December 2020

Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin

1 reference

12 December 2020

Proischemic complications of dihydropyridine calcium channel blockers

1 reference

12 December 2020

Vasodilator and hypotensive effects of the optical isomers of nicardipine (YC-93), a new Ca2+-antagonist

1 reference

12 December 2020

The effect of grapefruit juice on cyclosporine and prednisone metabolism in transplant patients

1 reference

12 December 2020

Grapefruit juice alters the systemic bioavailability and cardiac repolarization of terfenadine in poor metabolizers of terfenadine

1 reference

12 December 2020

Inhibition of 17β-estradiol metabolism by grapefruit juice in ovariectomized women

1 reference

12 December 2020

Electrophysiologic effects of dextro- and levo-verapamil on sinus node and AV node function in humans

1 reference

12 December 2020

Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues

1 reference

12 December 2020

Grapefruit juice-felodipine interaction: effect of naringin and 6',7'-dihydroxybergamottin in humans

1 reference

12 December 2020

[Rhabdomyolysis in patients treated with simvastatin and cyclosporin: role of the hepatic cytochrome P450 enzyme system activity]

1 reference

12 December 2020

Activation and inhibition of benzo(a)pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occurring flavonoids

1 reference

12 December 2020

Itraconazole affects single-dose terfenadine pharmacokinetics and cardiac repolarization pharmacodynamics

1 reference

12 December 2020

Grapefruit juice increases oral nimodipine bioavailability

1 reference

12 December 2020

Effect of grapefruit juice on blood cyclosporin concentration

1 reference

12 December 2020

Disposition of intravenous and oral cyclosporine after administration with grapefruit juice

1 reference

12 December 2020

Lacking effect of grapefruit juice on theophylline pharmacokinetics

1 reference

12 December 2020

Antihypertensive efficacy of the calcium-antagonist felodipine in patients with persisting hypertension on beta-adrenoceptor blocker therapy. The Canadian Felodipine Study Group

1 reference

12 December 2020

Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics

1 reference

12 December 2020

Itraconazole drastically increases plasma concentrations of lovastatin and lovastatin acid

1 reference

12 December 2020

Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation

1 reference

12 December 2020

First-pass metabolism of cyclosporin by the gut

1 reference

12 December 2020

Rhabdomyolysis from the coadministration of lovastatin and the antifungal agent itraconazole

1 reference

12 December 2020

The cardiac effects of terfenadine after inhibition of its metabolism by grapefruit juice

1 reference

12 December 2020

Identification of 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice

1 reference

12 December 2020

Pravastatin-induced rhabdomyolysis in a patient with mixed connective tissue disease

1 reference

12 December 2020

Erythromycin-felodipine interaction: Magnitude, mechanism, and comparison with grapefruit juice*

1 reference

12 December 2020

Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences

1 reference

12 December 2020

Lack of effect of grapefruit juice on diltiazem bioavailability in normal subjects

1 reference

12 December 2020

Effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of quinidine in healthy volunteers

1 reference

12 December 2020

Specific CYP3A4 inhibitors in grapefruit juice: furocoumarin dimers as components of drug interaction

1 reference

12 December 2020