Toll-like receptor signalling (Q24570126)

Nature Reviews Immunology

Europe PubMed Central

title

Toll-like receptor signalling (English)

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1

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author name string

Kiyoshi Takeda

series ordinal

2

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language of work or name

English

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publication date

July 2004

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published in

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volume

4

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issue

7

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page(s)

499-511

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cites work

Innate immune recognition

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Innate immune sensing and its roots: the story of endotoxin

31 March 2020

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Toll-like receptors and innate immunity

31 March 2020

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Toll-like receptors: critical proteins linking innate and acquired immunity

31 March 2020

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The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

31 March 2020

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The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

31 March 2020

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Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways

31 March 2020

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Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

31 March 2020

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

31 March 2020

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Leucine-rich repeats and pathogen recognition in Toll-like receptors.

31 March 2020

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Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

31 March 2020

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The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily

31 March 2020

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Subcellular localization of Toll-like receptor 3 in human dendritic cells

31 March 2020

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TLR9 signals after translocating from the ER to CpG DNA in the lysosome

31 March 2020

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31 March 2020

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IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

31 March 2020

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MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

31 March 2020

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MyD88, an adapter protein involved in interleukin-1 signaling

31 March 2020

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Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.

31 March 2020

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Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members

31 March 2020

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Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase

31 March 2020

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IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

31 March 2020

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Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production

31 March 2020

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IL-1 receptor-associated kinase modulates host responsiveness to endotoxin.

31 March 2020

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Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

31 March 2020

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Pyogenic bacterial infections in humans with IRAK-4 deficiency

31 March 2020

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Tumor necrosis factor receptor-associated factors (TRAFs)

31 March 2020

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Distinct molecular mechanism for initiating TRAF6 signalling

31 March 2020

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Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

31 March 2020

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TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway

31 March 2020

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TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction

31 March 2020

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TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway

31 March 2020

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TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling

31 March 2020

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Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling

31 March 2020

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Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

31 March 2020

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

31 March 2020

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

31 March 2020

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Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

31 March 2020

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The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways

31 March 2020

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Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase

31 March 2020

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Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

31 March 2020

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Unresponsiveness of MyD88-deficient mice to endotoxin

31 March 2020

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Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes

31 March 2020

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Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation

31 March 2020

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TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages.

31 March 2020

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Endotoxin-induced maturation of MyD88-deficient dendritic cells

31 March 2020

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Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

31 March 2020

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Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

31 March 2020

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Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

31 March 2020

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TIRAP: an adapter molecule in the Toll signaling pathway

31 March 2020

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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

31 March 2020

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Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

31 March 2020

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The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

31 March 2020

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Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

31 March 2020

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TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

31 March 2020

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TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling

31 March 2020

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TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

31 March 2020

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LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF

31 March 2020

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TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.

31 March 2020

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The Toll-IL-1 receptor adaptor family grows to five members.

31 March 2020

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TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM.

31 March 2020

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Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300.

31 March 2020

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IRF family of transcription factors as regulators of host defense

31 March 2020

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On the role of IRF in host defense

31 March 2020

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The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors

31 March 2020

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Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction

31 March 2020

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Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA.

31 March 2020

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Triggering the interferon antiviral response through an IKK-related pathway

31 March 2020

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IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

31 March 2020

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IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

31 March 2020

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Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...

31 March 2020

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RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

31 March 2020

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Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

31 March 2020

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Negative regulation of toll-like receptor-mediated signaling by Tollip

31 March 2020

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Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal

31 March 2020

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Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling

31 March 2020

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Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex

31 March 2020

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Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein

31 March 2020

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The role of PI3K in immune cells

31 March 2020

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Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway

31 March 2020

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Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages

31 March 2020

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Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cells

31 March 2020

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PI3K-mediated negative feedback regulation of IL-12 production in DCs

31 March 2020

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ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

31 March 2020

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Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis

31 March 2020

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Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.

31 March 2020

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Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn

31 March 2020

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Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3

31 March 2020

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TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

31 March 2020

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IRAK-M is a negative regulator of Toll-like receptor signaling

31 March 2020

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Negative regulation of cytokine signaling pathways

31 March 2020

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Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs

31 March 2020

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SOCS1/JAB is a negative regulator of LPS-induced macrophage activation

31 March 2020

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SOCS-1 participates in negative regulation of LPS responses

31 March 2020

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Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

31 March 2020

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SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling

31 March 2020

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ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance

31 March 2020

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Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection

31 March 2020

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Mycobacterial infection in MyD88-deficient mice

31 March 2020

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Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice

31 March 2020

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Cutting Edge: Protective Cell-Mediated Immunity to Listeria monocytogenes in the Absence of Myeloid Differentiation Factor 88

31 March 2020

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Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection

31 March 2020

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NODs: intracellular proteins involved in inflammation and apoptosis

31 March 2020

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Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways.

31 March 2020

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Viral infection switches non-plasmacytoid dendritic cells into high interferon producers.

31 March 2020

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Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.

31 March 2020

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Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection

31 March 2020

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Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins

31 March 2020

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Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses

31 March 2020

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Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

31 March 2020

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Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

31 March 2020

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Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2

31 March 2020

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Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin

31 March 2020

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Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation

31 March 2020

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Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent.

31 March 2020

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Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.

31 March 2020

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Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages.

31 March 2020

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The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.

31 March 2020

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Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.

31 March 2020

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Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol

31 March 2020

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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

31 March 2020

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Murine retroviruses activate B cells via interaction with toll-like receptor 4

31 March 2020

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Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway

31 March 2020

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Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex

31 March 2020

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HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway

31 March 2020

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The extra domain A of fibronectin activates Toll-like receptor 4.

31 March 2020

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Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4.

31 March 2020

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Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4.

31 March 2020

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Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4.

31 March 2020

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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

31 March 2020

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Discrimination of bacterial lipoproteins by Toll-like receptor 6

31 March 2020

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The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors

31 March 2020

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Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

31 March 2020

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Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

31 March 2020

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Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

31 March 2020

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Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

31 March 2020

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A Toll-like receptor recognizes bacterial DNA

31 March 2020

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A toll-like receptor that prevents infection by uropathogenic bacteria

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1391

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

195351

1023753307

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195351

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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