Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells (Q24552563)

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D Kipling

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M Morris

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P Hepburn

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J Skinner

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A Bounacer

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F S Wyllie

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M Ivan

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J Bartek

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D Wynford-Thomas

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J A Bond

Molecular and Cellular Biology

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language of work or name

English

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publication date

August 2000

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published in

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volume

20

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issue

15

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page(s)

5690-9

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cites work

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Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis

27 September 2017

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The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

27 September 2017

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27 September 2017

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RhoA stimulates p27(Kip) degradation through its regulation of cyclin E/CDK2 activity

27 September 2017

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27 September 2017

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Cyclin D3: requirement for G1/S transition and high abundance in quiescent tissues suggest a dual role in proliferation and differentiation

27 September 2017

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Dissociation of telomere dynamics from telomerase activity in human thyroid cancer cells.

27 September 2017

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Inactivation of p16 in human mammary epithelial cells by CpG island methylation

27 September 2017

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A requirement for cyclin D3-cyclin-dependent kinase (cdk)-4 assembly in the cyclic adenosine monophosphate-dependent proliferation of thyrocytes

27 September 2017

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27 September 2017

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Overcoming cellular senescence in human cancer pathogenesis

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Aberrant p27kip1 expression in endocrine and other tumors

27 September 2017

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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

27 September 2017

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Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

27 September 2017

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27 September 2017

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27 September 2017

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Telomerase activity in normal and malignant hematopoietic cells

27 September 2017

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Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity

27 September 2017

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Spontaneous de-differentiation correlates with extended lifespan in transformed thyroid epithelial cells: an epigenetic mechanism of tumour progression?

27 September 2017

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Presence of mutations in all three ras genes in human thyroid tumors

27 September 2017

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Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells.

27 September 2017

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Differential patterns of cell cycle regulatory proteins expression in transgenic models of thyroid tumours.

30 May 2018

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Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

30 May 2018

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30 May 2018

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30 May 2018

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p27Kip1 is expressed transiently in developing myotomes and enhances myogenesis

30 May 2018

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30 May 2018

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30 May 2018

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30 May 2018

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30 May 2018

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30 May 2018

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30 May 2018

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30 May 2018

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28 November 2018

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Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86042

p19ARF links the tumour suppressor p53 to Ras

28 November 2018

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p27Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation.

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86042

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28 November 2018

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Escape from senescence in human diploid fibroblasts induced directly by mutant p53.

28 November 2018

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Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

28 November 2018

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12 December 2020

Prevalence of ras gene mutations in human colorectal cancers

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12 December 2020

High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis

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12 December 2020

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

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12 December 2020

Downregulation of p27KIP1 and Ki67/Mib1 labeling index support the classification of thyroid carcinoma into prognostically relevant categories

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12 December 2020

High frequency deletion of the tumour suppressor gene P16INK4a (MTS1) in human thyroid cancer cell lines

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12 December 2020

Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells

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12 December 2020

Abnormalities of the P16INK4A gene in thyroid cancer cell lines

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12 December 2020

Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27

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12 December 2020