Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathways (Q24323279)

GOA release 2020-03-11

NF-kappaB binding

1 reference

GOA release 2020-03-11

1 reference

Unsong Oh

2

0 references

Lee Ratner

8

object named as

Lee Ratner

0 references

Steven Jacobson

9

object named as

Steven Jacobson

0 references

author name string

Christian Grant

1

0 references

Kazunori Fugo

3

0 references

Norihiro Takenouchi

4

0 references

Caitlin Griffith

5

0 references

Karen Yao

6

0 references

Timothy E Newhook

Creative Commons CC0 License

7

0 references

language of work or name

English

0 references

publication date

April 2006

0 references

published in

PLOS Pathogens

0 references

volume

2

0 references

page(s)

e33

0 references

issue

4

0 references

copyright license

start time

28 April 2006

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

cites work

Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells

1 reference

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Specific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complex

19 March 2017

1 reference

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Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions

19 March 2017

1 reference

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Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat

19 March 2017

1 reference

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

19 March 2017

1 reference

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Control of regulatory T cell development by the transcription factor Foxp3

19 March 2017

1 reference

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The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis

19 March 2017

1 reference

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Transcriptional regulation by the phosphorylation-dependent factor CREB

19 March 2017

1 reference

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Modulation of Th1 activation and inflammation by the NF-kappaB repressor Foxj1

19 March 2017

1 reference

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Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

19 March 2017

1 reference

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An essential role for Scurfin in CD4+CD25+ T regulatory cells

7 April 2017

1 reference

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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

7 April 2017

1 reference

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X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

7 April 2017

1 reference

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An inducible transcription factor activates expression of human immunodeficiency virus in T cells

7 April 2017

1 reference

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Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

7 April 2017

1 reference

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Reduced Foxp3 protein expression is associated with inflammatory disease during human t lymphotropic virus type 1 Infection

7 April 2017

1 reference

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Virus-induced dysfunction of CD4+CD25+ T cells in patients with HTLV-I-associated neuroimmunological disease

27 September 2017

1 reference

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FOXP3 acts as a rheostat of the immune response

27 September 2017

1 reference

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Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.

27 September 2017

1 reference

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Forkhead-box transcription factors and their role in the immune system

27 September 2017

1 reference

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Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis

27 September 2017

1 reference

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CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

Increased expression of human T lymphocyte virus type I (HTLV-I) Tax11-19 peptide-human histocompatibility leukocyte antigen A*201 complexes on CD4+ CD25+ T Cells detected by peptide-specific, major histocompatibility complex-restricted antibodies i

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

CD4+ CD25+ suppressor T cells: more questions than answers

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8(+) T cells, and disease severity in HTLV-1-associated myelopathy (HAM/TSP).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

Tolerance and autoimmunity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

Increased activated human T cell lymphotropic virus type I (HTLV-I) Tax11-19-specific memory and effector CD8+ cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis: correlation with HTLV-I provirus load

27 September 2017

1 reference

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Mechanisms of NF-kappaB activation by the HTLV type 1 tax protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

In vitro CD4+ lymphocyte transformation and infection in a rabbit model with a molecular clone of human T-cell lymphotrophic virus type 1

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

Mechanism of DNA-binding enhancement by the human T-cell leukaemia virus transactivator Tax.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

Construction and characterization of infectious human T-cell leukemia virus type 1 molecular clones.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

Tax protein of HTLV-1 interacts with the Rel homology domain of NF-kappa B p65 and c-Rel proteins bound to the NF-kappa B binding site and activates transcription.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

NFAT1 enhances HIV-1 gene expression in primary human CD4 T cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

The AP-1 Site and the cAMP- and Serum Response Elements of the c-fosGene Are Constitutively OccupiedIn Vivo

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

Relationship of CD4+CD25+ regulatory T cells to immune status in HIV-infected patients.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

Transcription factor binding and histone modifications on the integrated proviral promoter in human T-cell leukemia virus-I-infected T-cells.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

Analysis of CREB mutants in Tax complex formation and trans-activation.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

p300 and p300/cAMP-responsive element-binding protein associated factor interact with human T-cell lymphotropic virus type-1 Tax in a multi-histone acetyltransferase/activator-enhancer complex

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

Recognition of bZIP proteins by the human T-cell leukaemia virus transactivator Tax.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1447668

Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16652169

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16652169

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

FOXP3 mRNA levels are decreased in peripheral blood CD4+ lymphocytes from HIV-positive patients

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16652169

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PPAT.0020033

1 reference

725879

725879

1 reference

1 reference

1 reference