Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease (Q24317439)

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R Perez

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E H Koo

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D J Selkoe

Proceedings of the National Academy of Sciences of the United States of America

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language of work or name

English

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publication date

22 July 1997

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published in

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volume

94

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issue

15

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page(s)

8208-13

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cites work

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

19 March 2017

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

19 March 2017

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Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3

19 March 2017

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

19 March 2017

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Evidence that production and release of amyloid beta-protein involves the endocytic pathway

19 March 2017

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Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

19 March 2017

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

19 March 2017

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

19 March 2017

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Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

7 April 2017

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Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

27 September 2017

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The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum

27 September 2017

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

27 September 2017

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Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

27 September 2017

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Specific transcellular binding between membrane proteins crucial to Alzheimer disease

27 September 2017

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Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

27 September 2017

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Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

27 September 2017

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Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

27 September 2017

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

27 September 2017

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The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

27 September 2017

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Microtubules, membrane traffic, and cell organization

27 September 2017

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Alzheimer's disease: genotypes, phenotypes, and treatments

27 September 2017

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Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

27 September 2017

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Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

30 May 2018

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Cerebral amyloidosis, ageing and Alzheimer's disease; a contribution from studies on Down's syndrome.

30 May 2018

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The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway

30 May 2018

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The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

30 May 2018

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Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

21 January 2018

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Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.94.15.8208

Reduced temperature prevents transfer of a membrane glycoprotein to the cell surface but does not prevent terminal glycosylation

21 January 2018

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The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

21 January 2018

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12 December 2020

Protein topology of presenilin 1

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12 December 2020

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins

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12 December 2020

Enhanced release of amyloid beta-protein from codon 670/671 "Swedish" mutant beta-amyloid precursor protein occurs in both secretory and endocytic pathways

1 reference

12 December 2020

Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome

1 reference

12 December 2020