Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling (Q24317374)

RAR related orphan receptor A

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

hormone receptor binding

1 reference

GOA release 2020-03-11

author name string

Eun-Jin Kim

1

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Young-Gun Yoo

2

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Woo-Kyeom Yang

3

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Young-Soun Lim

4

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Tae-Young Na

5

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In-Kyu Lee

6

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Mi-Ock Lee

Arteriosclerosis, Thrombosis, and Vascular Biology

7

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language of work or name

English

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publication date

October 2008

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published in

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volume

28

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page(s)

1796-802

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issue

10

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cites work

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The structural integrity of ROR alpha isoforms is mutated in staggerer mice: cerebellar coexpression of ROR alpha1 and ROR alpha4.

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Regional variation and absence of large neurons in the cerebellum of the staggerer mouse

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Identification of the human ApoAV gene as a novel RORalpha target gene

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Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications

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Regulation of angiogenesis by hypoxia-inducible factor 1.

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Expression and regulation of the nuclear receptor RORalpha in human vascular cells

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The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes

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Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

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X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha

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Disruption of the nuclear hormone receptor RORalpha in staggerer mice

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Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1.

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6-Mercaptopurine, an activator of Nur77, enhances transcriptional activity of HIF-1alpha resulting in new vessel formation

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Retinoic acid receptor-related orphan receptor (ROR) alpha4 is the predominant isoform of the nuclear receptor RORalpha in the liver and is up-regulated by hypoxia in HepG2 human hepatoma cells

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The gene encoding human retinoic acid-receptor-related orphan receptor alpha is a target for hypoxia-inducible factor 1.

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Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

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Thiazolidine diones, specific ligands of the nuclear receptor retinoid Z receptor/retinoid acid receptor-related orphan receptor alpha with potent antiarthritic activity.

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Transcriptional regulation of apolipoprotein A-I gene expression by the nuclear receptor RORalpha

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Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

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Transcriptional regulation of human Rev-erbalpha gene expression by the orphan nuclear receptor retinoic acid-related orphan receptor alpha

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Hypoxia-induced activation of the retinoic acid receptor-related orphan receptor alpha4 gene by an interaction between hypoxia-inducible factor-1 and Sp1.

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Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A

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Novel function of orphan nuclear receptor Nur77 in stabilizing hypoxia-inducible factor-1alpha

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Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

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7 January 2021

The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response

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Transcriptional activation of the nuclear receptor RZR alpha by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand

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Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors

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7 January 2021

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

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Hypoxia-Inducible Factor-1 (HIF-1)

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The gene encoding fibrinogen-beta is a target for retinoic acid receptor-related orphan receptor alpha

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7 January 2021

Recent advances in the mechanisms of action and physiological functions of the retinoid-related orphan receptors (RORs).

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7 January 2021

The positive regulation of p53 by the tumor suppressor VHL.

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7 January 2021