Evidence that alpha-synuclein functions as a negative regulator of Ca(++)-dependent alpha-granule release from human platelets (Q24306916)

GOA release 2020-03-11

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Sang Myun Park

1

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Han Young Jung

2

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Hyun Ok Kim

3

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Hyangshuk Rhim

4

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Seung R Paik

5

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Kwang Chul Chung

6

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Jeon Han Park

7

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Jongsun Kim

Platelet mitochondrial respiratory chain function in Parkinson's disease.

8

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language of work or name

English

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publication date

1 October 2002

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published in

Blood

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volume

100

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page(s)

2506-14

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issue

7

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cites work

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NACP, a synaptic protein involved in Alzheimer's disease, is differentially regulated during megakaryocyte differentiation

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Molecular Mechanisms of Platelet Exocytosis: Requirements for α-Granule Release

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Synoretin--A new protein belonging to the synuclein family

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Platelets as a model for neurones?

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Alpha-synuclein and Parkinson's disease

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Identification of two distinct synucleins from human brain

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Platelet morphology in Parkinson's disease: an electron microscopic study

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[3H] dopamine uptake by platelet storage granules in Parkinson's disease

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Measurement of secretion of lysosomal acid glycosidases

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A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

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Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

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alpha-synuclein promotes mitochondrial deficit and oxidative stress

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Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

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Plasma uptake of dopamine and 5-hydroxytryptamine and plasma-catecholamine levels in patients with Huntington's chorea

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Human platelet calcium mobilisation in response to beta-amyloid (25-35): buffer dependency and unchanged response in Alzheimer's disease

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Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy.

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Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

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Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

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Stress-induced aggregation profiles of GST-alpha-synuclein fusion proteins: role of the C-terminal acidic tail of alpha-synuclein in protein thermosolubility and stability

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Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins

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Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

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Alpha-synuclein in Lewy bodies

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

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Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

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Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations

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Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli

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alpha-Synuclein membrane interactions and lipid specificity

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Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.

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Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein

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The cytoskeleton of the resting human blood platelet: structure of the membrane skeleton and its attachment to actin filaments

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Mechanisms of actin rearrangements mediating platelet activation

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Structural changes in alpha-synuclein affect its chaperone-like activity in vitro

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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Family study of platelet membrane fluidity in Alzheimer's disease.

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Platelet monoamine oxidase B activity in parkinsonian patients

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Platelet aggregation in patients with Parkinson's disease

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Uptake and efflux of 14C-dopamine in platelets: Evidence for a generalized defect in Parkinson's disease

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Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

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