Progressive degeneration of human neural stem cells caused by pathogenic LRRK2 (Q24301070)

23

Juan Carlos Izpisua Belmonte

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Ignacio Sancho-Martinez

Ignacio Sancho-Martinez

22

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Nuria Montserrat

Nuria Montserrat

6

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Emmanuel Nivet

4

Emmanuel Nivet

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Guang-Hui Liu

1

Guang-Hui Liu

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Rupa Devi Soligalla

17

Rupa Devi Soligalla

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April Goebl

15

April Goebl

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Ilir Dubova

18

Ilir Dubova

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author name string

Jing Qu

2

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Keiichiro Suzuki

3

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Mo Li

5

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Fei Yi

7

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Xiuling Xu

8

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Sergio Ruiz

9

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Weiqi Zhang

10

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Ulrich Wagner

11

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Audrey Kim

12

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Bing Ren

13

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Ying Li

14

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Jessica Kim

16

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James Thompson

19

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John Yates

20

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Concepcion Rodriguez Esteban

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

21

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language of work or name

English

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publication date

22 November 2012

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published in

Nature

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volume

491

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issue

7425

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page(s)

603-7

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504651

Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression

19 March 2017

1 reference

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14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504651

Lamin A-dependent nuclear defects in human aging

19 March 2017

1 reference

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Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?

19 March 2017

1 reference

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Lamin B1 duplications cause autosomal dominant leukodystrophy

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504651

Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504651

Clinical and pathological characteristics of LRRK2 G2019S patients with PD.

19 March 2017

1 reference

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Diseases in a dish: modeling human genetic disorders using induced pluripotent cells

27 September 2017

1 reference

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Efficient and accurate homologous recombination in hESCs and hiPSCs using helper-dependent adenoviral vectors

27 September 2017

1 reference

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Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons

27 September 2017

1 reference

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Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice

27 September 2017

1 reference

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Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504651

Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors

27 September 2017

1 reference

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Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504651

Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504651

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504651

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504651

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504651

Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504651

Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504651

Parkinson's disease: insights from pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504651

Diseases of the nuclear envelope

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504651

Highly efficient transient gene expression and gene targeting in primate embryonic stem cells with helper-dependent adenoviral vectors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504651

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504651

Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504651

Abnormalities of the nucleus and nuclear inclusions in neurodegenerative disease: a work in progress

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504651

Proteasome inhibition modeling nigral neuron degeneration in Parkinson's disease

27 September 2017

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE11557

Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE11557

Lower cognitive performance in healthy G2019S LRRK2 mutation carriers

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE11557

A mutation in VAPB that causes amyotrophic lateral sclerosis also causes a nuclear envelope defect

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23075850

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE11557

1 reference

Dimensions Publication ID

1028278

1025324656

0 references

1028278

1 reference

1 reference

1 reference