Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy (Q24300975)

GOA release 2020-03-11

protein ubiquitination

1 reference

6

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Matthew E Gegg

Matthew E Gegg

1

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Manuel Rojo

Manuel Rojo

4

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Anthony H V Schapira

5

Anthony H V Schapira

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J M Cooper

2

J Mark Cooper

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author name string

Kai-Yin Chau

Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

3

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language of work or name

English

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publication date

15 December 2010

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published in

Human Molecular Genetics

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volume

19

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page(s)

4861-70

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issue

24

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cites work

1 reference

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

19 March 2017

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Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling

19 March 2017

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Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission

19 March 2017

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

19 March 2017

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PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

19 March 2017

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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

19 March 2017

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A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

19 March 2017

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

19 March 2017

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Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration

19 March 2017

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Ubiquitin-proteasome-dependent degradation of a mitofusin, a critical regulator of mitochondrial fusion

19 March 2017

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Chaperone-mediated autophagy markers in Parkinson disease brains

19 March 2017

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Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

19 March 2017

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Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

19 March 2017

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Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1

19 March 2017

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Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

19 March 2017

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Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo

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Preparation and properties of mitochondria derived from synaptosomes

19 March 2017

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19 March 2017

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

7 April 2017

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Mitochondria supply membranes for autophagosome biogenesis during starvation

7 April 2017

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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

7 April 2017

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Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin

7 April 2017

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PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

7 April 2017

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A role for ubiquitin in selective autophagy

7 April 2017

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The PINK1/Parkin pathway regulates mitochondrial morphology

7 April 2017

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

7 April 2017

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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

7 April 2017

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

7 April 2017

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Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

7 April 2017

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Molecular and clinical prodrome of Parkinson disease: implications for treatment

7 April 2017

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The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway

27 September 2017

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Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex

27 September 2017

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Proteasome system of protein degradation and processing

27 September 2017

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Protein degradation, aggregation, and misfolding

27 September 2017

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Mitochondrial fusion proteins: dual regulators of morphology and metabolism

27 September 2017

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Parkin-mediated ubiquitin signalling in aggresome formation and autophagy

27 September 2017

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The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy

27 September 2017

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The PINK1/Parkin pathway: a mitochondrial quality control system?

27 September 2017

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Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

27 September 2017

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Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.

27 September 2017

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Parkin stabilizes PINK1 through direct interaction

27 September 2017

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27 September 2017

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PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

27 September 2017

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Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells

27 September 2017

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Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux

27 September 2017

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27 September 2017

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Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

27 September 2017

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