α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner (Q24300131)

identical protein binding

1 reference

RAB8A, member RAS oncogene family

1 reference

Synuclein, alpha

1 reference

1 reference

18

0 references

Christian Griesinger

12

0 references

Ane Martín Anduaga

Ane Martín Anduaga

4

0 references

Carlo Breda

Carlo Breda

5

0 references

Claudio O. Fernandez

Claudio O Fernandez

11

0 references

Gerhard H Braus

Gerhard H Braus

10

0 references

Roger S. Goody

Roger S Goody

14

0 references

Aymelt Itzen

15

Aymelt Itzen

0 references

author name string

Guowei Yin

1

0 references

Tomas Lopes da Fonseca

2

0 references

Sibylle E Eisbach

3

0 references

Maria L Orcellet

6

0 references

Éva M Szegő

7

0 references

Patricia Guerreiro

8

0 references

Diana F Lázaro

9

0 references

Stefan Becker

13

0 references

Flaviano Giorgini

16

0 references

Tiago F Outeiro

Amyloidogenic protein-membrane interactions: mechanistic insight from model systems

17

0 references

language of work or name

English

0 references

publication date

October 2014

0 references

published in

Neurobiology of Disease

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volume

70

0 references

page(s)

149-61

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Characterization of kinases involved in the phosphorylation of aggregated α-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Sub-angstrom modeling of complexes between flexible peptides and globular proteins.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Conformational properties of alpha-synuclein in its free and lipid-associated states

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Golgi fragmentation is Rab and SNARE dependent in cellular models of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Aggregation of α-synuclein in S. cerevisiae is associated with defects in endosomal trafficking and phospholipid biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

PLK2 modulates α-synuclein aggregation in yeast and mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Identification of two distinct synucleins from human brain

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Molecular mechanisms of alpha-synuclein neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

In vivo alpha-synuclein overexpression in rodents: a useful model of Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

The genetics of Parkinson's syndromes: a critical review

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Structure and properties of a complex of α-synuclein and a single-domain camelid antibody

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Alpha-synuclein binding to rab3a in multiple system atrophy.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Chaperone-assisted production of active human Rab8A GTPase in Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Parkinson's disease: insights from non-traditional model organisms

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

GTPases involved in vesicular trafficking: structures and mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Dependence of alpha-synuclein aggregate morphology on solution conditions

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Staging of brain pathology related to sporadic Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Structural and functional implications of C-terminal regions of alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Impact of the acidic C-terminal region comprising amino acids 109-140 on alpha-synuclein aggregation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Role of different regions of alpha-synuclein in the assembly of fibrils.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Detection of transient interchain interactions in the intrinsically disordered protein alpha-synuclein by NMR paramagnetic relaxation enhancement

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Mars -- robust automatic backbone assignment of proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Backbone assignment of proteins with known structure using residual dipolar couplings

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

A Drosophila model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Neurodegenerative disease: amyloid pores from pathogenic mutations.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Alpha-synuclein in Lewy bodies

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Alpha-synuclein: from secretion to dysfunction and death

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

alpha-Synuclein is phosphorylated in synucleinopathy lesions

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Rab GTPases as coordinators of vesicle traffic

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

The many faces of α-synuclein: from structure and toxicity to therapeutic target

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

alpha-Synuclein produces a long-lasting increase in neurotransmitter release

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Structure and properties of alpha-synuclein and other amyloids determined at the amino acid level

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

The fold of alpha-synuclein fibrils

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

In vivo demonstration that alpha-synuclein oligomers are toxic

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Electrostatics of nanosystems: application to microtubules and the ribosome

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Phosphorylation of synucleins by members of the Polo-like kinase family

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Phosphorylation of α-synuclein protein at Ser-129 reduces neuronal dysfunction by lowering its membrane binding property in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

α-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Lewy body-like α-synuclein aggregates resist degradation and impair macroautophagy

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Structure and dynamics of micelle-bound human alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

The relation of hostile nonverbal communication styles to popularity in preadolescent children.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Rab8 regulates basolateral secretory, but not recycling, traffic at the recycling endosome

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

An internal domain of Exo70p is required for actin-independent localization and mediates assembly of specific exocyst components

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in α-synuclein transgenic C . elegans

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Rab11 rescues synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Rosetta FlexPepDock web server--high resolution modeling of peptide-protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Neuropathology of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Polycation-induced oligomerization and accelerated fibrillation of human alpha-synuclein in vitro

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Structural mechanisms for regulation of membrane traffic by rab GTPases

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

α-Synuclein: membrane interactions and toxicity in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

alpha-Synuclein and neuronal cell death

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Formation of toxic oligomeric alpha-synuclein species in living cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Pre-fibrillar α-synuclein mutants cause Parkinson's disease-like non-motor symptoms in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021

Assaying locomotor, learning, and memory deficits in Drosophila models of neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FJ.NBD.2014.06.018

7 January 2021