Molecular determinants for the interaction of the valvulopathic anorexigen norfenfluramine with the 5-HT2B receptor (Q24300121)

5-hydroxytryptamine receptor 2B

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5-hydroxytryptamine receptor 2A

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serotonin binding

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author name string

Vincent Setola

1

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Malgorzata Dukat

2

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Richard A Glennon

3

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Bryan L Roth

Binding of amino acid side chains to preformed cavities: interaction of serine proteinases with turkey ovomucoid third domains with coded and noncoded P1 residues

4

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language of work or name

English

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publication date

July 2005

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published in

Molecular Pharmacology

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volume

68

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issue

1

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page(s)

20-33

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cites work

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7 January 2021

Water molecules participate in proteinase-inhibitor interactions: crystal structures of Leu18, Ala18, and Gly18 variants of turkey ovomucoid inhibitor third domain complexed with Streptomyces griseus proteinase B.

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Binding of amino acid side-chains to S1 cavities of serine proteinases

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7 January 2021

Evidence that d-fenfluramine anorexia is mediated by 5-HT1 receptors

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7 January 2021

Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia

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The ability of certain anorexic drugs to suppress food consumption depends on the nutrient composition of the test diet

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7 January 2021

Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents

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7 January 2021

Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors

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7 January 2021

5-Hydroxytryptamine2-family receptors (5-hydroxytryptamine2A, 5-hydroxytryptamine2B, 5-hydroxytryptamine2C): where structure meets function

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7 January 2021

Histologic changes in three explanted native cardiac valves following use of fenfluramines

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7 January 2021

Energetic origins of specificity of ligand binding in an interior nonpolar cavity of T4 lysozyme

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7 January 2021

Thermodynamics of Ligand Binding to Acyl-Coenzyme A Binding Protein Studied by Titration Calorimetry†

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7 January 2021

Long-term weight control study. III (weeks 104 to 156). An open-label study of dose adjustment of fenfluramine and phentermine

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7 January 2021

Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension

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Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

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7 January 2021

Valvular heart disease associated with fenfluramine-phentermine

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7 January 2021

Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist

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7 January 2021

The second extracellular loop of the dopamine D2 receptor lines the binding-site crevice

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7 January 2021

Thermodynamics and molecular simulation analysis of hydrophobic substrate recognition by aminotransferases.

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7 January 2021

Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6.

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7 January 2021

The serotonin binding site of human and murine 5-HT2B receptors: molecular modeling and site-directed mutagenesis

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Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors

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7 January 2021

Paracoccus denitrificans aromatic amino acid aminotransferase: a model enzyme for the study of dual substrate recognition mechanism

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7 January 2021

Effect of norfenfluramine and two structural analogues on brain 5-hydroxyindoles and serum prolactin in rats.

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7 January 2021

Identification of conserved aromatic residues essential for agonist binding and second messenger production at 5-hydroxytryptamine2A receptors

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7 January 2021

3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro

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7 January 2021

Activation of central melanocortin pathways by fenfluramine

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7 January 2021

Crystal structure of rhodopsin: A G protein-coupled receptor

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7 January 2021

Primary pulmonary hypertension and fenfluramine use

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Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications

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7 January 2021

G-protein-coupled receptors at a glance

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7 January 2021

Primary pulmonary hypertension associated with the use of fenfluramine derivatives

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7 January 2021

Autopsy findings of heart and lungs in a patient with primary pulmonary hypertension associated with use of fenfluramine and phentermine

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7 January 2021

Molecular biology of serotonin receptors structure and function at the molecular level

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