Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F (Q24297195)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16844695%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

title

Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16844695%20AND%20SRC:MED&resulttype=core&format=json

Fibroblast growth factor receptor 2

27 December 2019

main subject

craniosynostosis

0 references

1 reference

protein homodimerization activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

1

1 reference

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27 December 2019

Mark Bothwell

5

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27 December 2019

author name string

Mark Hudson

2

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27 December 2019

Marianne L Seto

3

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27 December 2019

Michael L Cunningham

4

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27 December 2019

language of work or name

English

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publication date

14 July 2006

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Journal of Biological Chemistry

27 December 2019

published in

1 reference

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27 December 2019

volume

281

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27 December 2019

page(s)

27292-27305

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27 December 2019

issue

37

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Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction

27 December 2019

cites work

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Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

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FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.

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The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors

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Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA

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Decreased proliferation and altered differentiation in osteoblasts from genetically and clinically distinct craniosynostotic disorders

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Apoptosis in murine calvarial bone and suture development.

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Increased osteoblast apoptosis in apert craniosynostosis: role of protein kinase C and interleukin-1.

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Signaling by fibroblast growth factors (FGF) and fibroblast growth factor receptor 2 (FGFR2)-activating mutations blocks mineralization and induces apoptosis in osteoblasts

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Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome.

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Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand

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Constitutive activation of fibroblast growth factor receptor-2 by a point mutation associated with Crouzon syndrome.

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Ligand-independent activation of fibroblast growth factor receptors by point mutations in the extracellular, transmembrane, and kinase domains

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Constitutive receptor activation by Crouzon syndrome mutations in fibroblast growth factor receptor (FGFR)2 and FGFR2/Neu chimeras

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Activating mutations in the extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domain

21 January 2018

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Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers

21 January 2018

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Alternative intracellular routing of ErbB receptors may determine signaling potency

21 January 2018

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Ligand-induced lysosomal epidermal growth factor receptor (EGFR) degradation is preceded by proteasome-dependent EGFR de-ubiquitination

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Statistical analysis of the protein environment of N-glycosylation sites: implications for occupancy, structure, and folding.

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Three putative N-glycosylation sites within the murine 5-HT3A receptor sequence affect plasma membrane targeting, ligand binding, and calcium influx in heterologous mammalian cells

21 January 2018

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Membrane heparan sulfate proteoglycan-supported FGF2-FGFR1 signaling: evidence in support of the "cooperative end structures" model.

21 January 2018

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In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria

21 January 2018

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Isolation and characterization of MC3T3-E1 preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential

21 January 2018

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Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth

21 January 2018

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Production of PtdInsP3 at endomembranes is triggered by receptor endocytosis

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21 January 2018

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21 January 2018

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Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis

21 January 2018

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Association of the signaling adaptor FRS2 with fibroblast growth factor receptor 1 (Fgfr1) is mediated by alternative splicing of the juxtamembrane domain

21 January 2018

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Energy boost: the Warburg effect returns in a new theory of cancer

21 January 2018

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Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL.

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21 January 2018

Identifiers

DOI

10.1074/JBC.M600448200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16844695%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference