PML regulates p53 stability by sequestering Mdm2 to the nucleolus (Q24296743)

PML nuclear body scaffold

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protein targeting

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Transformed mouse 3T3 cell double minute 2

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Ribosomal protein L11

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author

Pier Paolo Pandolfi

6

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Henning F Horn

Henning F Horn

4

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Pier Paolo Scaglioni

Pier Paolo Scaglioni

2

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Rosa Bernardi

Rosa Bernardi

1

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Karen Vousden

5

Karen H Vousden

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author name string

Stephan Bergmann

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

3

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language of work or name

English

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publication date

July 2004

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published in

Nature Cell Biology

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volume

6

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issue

7

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page(s)

665-72

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cites work

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The function of PML in p53-dependent apoptosis

20 April 2017

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Physical and functional interactions between PML and MDM2

20 April 2017

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MDM2 and Promyelocytic Leukemia Antagonize Each Other through Their Direct Interaction with p53

20 April 2017

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Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization

20 April 2017

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Regulation of HDM2 activity by the ribosomal protein L11

20 April 2017

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The role of PML in tumor suppression

20 April 2017

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PML protein isoforms and the RBCC/TRIM motif

20 April 2017

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Regulation of p53 activity in nuclear bodies by a specific PML isoform

20 April 2017

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Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway

20 April 2017

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PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

20 April 2017

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Role of PML and the PML-nuclear body in the control of programmed cell death

20 April 2017

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Directed proteomic analysis of the human nucleolus

20 April 2017

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Nucleolar Arf sequesters Mdm2 and activates p53

20 April 2017

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Cell cycle checkpoint signaling through the ATM and ATR kinases

20 April 2017

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The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation

20 April 2017

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Regulation of the p53 tumor suppressor protein

21 January 2018

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Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

21 January 2018

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Spontaneously immortalized cell lines obtained from adult Atm null mice retain sensitivity to ionizing radiation and exhibit a mutational pattern suggestive of oxidative stress

21 January 2018

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Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

21 January 2018

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Deconstructing PML-induced premature senescence

21 January 2018

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

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S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function

21 January 2018

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Regulation of p53 functions: let's meet at the nuclear bodies.

21 January 2018

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ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation

21 January 2018

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