Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling (Q24291843)

Growth factor receptor bound protein 2

GOA release 2020-03-11

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GOA release 2020-03-11

author name string

W Lu

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D Gong

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D Bar-Sagi

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P A Cole

Recruitment of the protein-tyrosine phosphatase SHP-2 to the C-terminal tyrosine of the prolactin receptor and to the adaptor protein Gab2.

4

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language of work or name

English

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publication date

October 2001

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published in

Molecular Cell

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volume

8

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issue

4

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page(s)

759-69

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cites work

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7 January 2021

Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression

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Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras

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7 January 2021

Divergent roles of SHP-2 in ERK activation by leptin receptors

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Nonhydrolyzable phosphotyrosyl mimetics for the preparation of phosphatase-resistant SH2 domain inhibitors.

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Protein-tyrosine phosphatases: structure, mechanism, and inhibitor discovery

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Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1

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Substrate specificities of catalytic fragments of protein tyrosine phosphatases (HPTP beta, LAR, and CD45) toward phosphotyrosylpeptide substrates and thiophosphotyrosylated peptides as inhibitors

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Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway.

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Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2

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7 January 2021

Semisynthesis of cytotoxic proteins using a modified protein splicing element

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SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases

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Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew

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Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

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7 January 2021

Crystal structure of the tyrosine phosphatase SHP-2

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7 January 2021

Signaling--2000 and beyond

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The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1.

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7 January 2021

Identification of a putative Syp substrate, the PDGF beta receptor

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A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

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Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2

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7 January 2021

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

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Expressed protein ligation: a general method for protein engineering

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Protein tyrosine phosphatases in signal transduction.

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A general method for site-specific incorporation of unnatural amino acids into proteins.

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7 January 2021

Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction

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Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps

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7 January 2021

corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso

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7 January 2021

Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains

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Src homology domain 2-containing tyrosine phosphatase 2 associates with intercellular adhesion molecule 1 to regulate cell survival

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Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells

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7 January 2021

Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals

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7 January 2021

pp60v-src phosphorylates and activates low molecular weight phosphotyrosine-protein phosphatase.

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7 January 2021

The SH2 tyrosine phosphatase shp2 is required for mammalian limb development.

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Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.

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Tyrosine kinases: modular signaling enzymes with tunable specificities

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7 January 2021

Domain interactions in protein tyrosine kinase Csk.

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Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

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7 January 2021

Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1.

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7 January 2021

Regulation of the low molecular weight phosphotyrosine phosphatase by phosphorylation at tyrosines 131 and 132.

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7 January 2021

37 Purification of protein-tyrosine phosphatases from human placenta

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7 January 2021

From form to function: signaling by protein tyrosine phosphatases.

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7 January 2021

Combinatorial control of the specificity of protein tyrosine phosphatases

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7 January 2021

Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation

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7 January 2021

Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage

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7 January 2021

Protein-tyrosine phosphatase SHP2 is positively linked to proteinase-activated receptor 2-mediated mitogenic pathway

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7 January 2021

A phosphotyrosine displacement mechanism for activation of Src by PTPalpha

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7 January 2021