KLRC4-KLRK1 readthrough (Q22675731)

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mammalian protein found in Homo sapiens

NKG2-D type II integral membrane protein
killer cell lectin-like receptor subfamily K member 1
NK cell receptor D
KLRC4-KLRK1
killer cell lectin-like receptor subfamily K, member 1
NKG2-D-activating NK receptor
KLRK1
NK Cell Lectin-Like Receptor Subfamily K

Language	Label	Description	Also known as
English	KLRC4-KLRK1 readthrough	mammalian protein found in Homo sapiens	NKG2-D type II integral membrane protein killer cell lectin-like receptor subfamily K member 1 NK cell receptor D KLRC4-KLRK1 killer cell lectin-like receptor subfamily K, member 1 NKG2-D-activating NK receptor KLRK1 NK Cell Lectin-Like Receptor Subfamily K

Statements

1 reference

13 November 2019

UniProt protein ID

C-type lectin-like/link domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P26718

C-type lectin fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P26718

pore-forming toxin

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

membrane proteins

1 reference

based on heuristic

inferred from GOA cell component → membrane

Natural killer cell receptor-like, C-type lectin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

C-type lectin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein homodimerization activity

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

protein binding

determination method

13 references

9 May 2019

An activating immunoreceptor complex formed by NKG2D and DAP10

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

The NKG2D ligand ULBP4 binds to TCRgamma9/delta2 and induces cytotoxicity to tumor cells through both TCRgammadelta and NKG2D.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

Four novel ULBP splice variants are ligands for human NKG2D.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

ULBP6/RAET1L is an additional human NKG2D ligand

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

Differential NKG2D binding to highly related human NKG2D ligands ULBP2 and RAET1G is determined by a single amino acid in the alpha2 domain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

MHC class Ib receptor activity

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

MHC class I protein binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

carbohydrate binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

signaling receptor activity

determination method

protein binding

determination method

14 references

1 January 2018

Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

1 January 2018

An activating immunoreceptor complex formed by NKG2D and DAP10

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

1 January 2018

CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

1 January 2018

A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

1 January 2018

ULBP6/RAET1L is an additional human NKG2D ligand

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

1 January 2018

Four novel ULBP splice variants are ligands for human NKG2D.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

1 January 2018

Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

1 January 2018

Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

1 January 2018

Differential NKG2D binding to highly related human NKG2D ligands ULBP2 and RAET1G is determined by a single amino acid in the alpha2 domain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

1 January 2018

Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

1 January 2018

The NKG2D ligand ULBP4 binds to TCRgamma9/delta2 and induces cytotoxicity to tumor cells through both TCRgammadelta and NKG2D.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

1 January 2018

A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

1 January 2018

Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

signaling receptor activity

determination method

3 references

9 May 2019

DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

Identification of CLEC12B, an inhibitory receptor on myeloid cells.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

integral component of plasma membrane

determination method

1 reference

9 May 2019

DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

determination method

3 references

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

1 January 2018

An activating immunoreceptor complex formed by NKG2D and DAP10

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

1 January 2018

A Structural basis for the association of DAP12 with mouse, but not human, NKG2D

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

external side of plasma membrane

determination method

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26718&geneProductId=UniProtKB:P26718

determination method

plasma membrane

determination method

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

Identification of CLEC12B, an inhibitory receptor on myeloid cells.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

determination method

4 references

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

A Structural basis for the association of DAP12 with mouse, but not human, NKG2D

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

An activating immunoreceptor complex formed by NKG2D and DAP10

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

biological process

cell differentiation

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

adaptive immune response

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

immune system process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

positive regulation of nitric oxide biosynthetic process

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

negative regulation of natural killer cell chemotaxis

determination method

1 reference

9 May 2019

Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

T cell costimulation

determination method

1 reference

9 May 2019

Tumor-associated MICA is shed by ADAM proteases

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

positive regulation of interferon-gamma production

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

stimulatory C-type lectin receptor signaling pathway

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

negative regulation of GTPase activity

determination method

1 reference

9 May 2019

Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

regulation of immune response

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

cellular response to lipopolysaccharide

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

signal transduction

determination method

1 reference

9 May 2019

DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

defense response to Gram-positive bacterium

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

innate immune response

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

natural killer cell mediated cytotoxicity

determination method

1 reference

9 May 2019

Identification of CLEC12B, an inhibitory receptor on myeloid cells.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

natural killer cell activation

determination method

3 references

1 January 2018

Tumor-associated MICA is shed by ADAM proteases

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

positive regulation of myeloid dendritic cell activation

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

negative regulation of GTPase activity

determination method

positive regulation of apoptotic process

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

negative regulation of natural killer cell chemotaxis

determination method

positive regulation of natural killer cell mediated cytotoxicity

determination method

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

A Structural basis for the association of DAP12 with mouse, but not human, NKG2D

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26718

determination method

C-type lectin-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P26718

Natural killer cell receptor-like, C-type lectin-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P26718

Identifiers

MeSH descriptor ID

subject named as

NK Cell Lectin-Like Receptor Subfamily K

0 references

D12.776.543.750.705.895.800.910

0 references

RefSeq protein ID

1 reference

4 April 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000240618

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000240618

ENSP00000446003

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000446003

ENSP00000379726

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000379726

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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