The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease (Q22254713)

cysteine-type endopeptidase activity involved in apoptotic process

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

M C Bordeaux

1

M C

Bordeaux

1 reference

8 February 2023

C Forcet

2

C

Forcet

1 reference

8 February 2023

L Granger

3

L

Granger

1 reference

8 February 2023

V Corset

4

V

Corset

1 reference

8 February 2023

C Bidaud

5

C

Bidaud

1 reference

8 February 2023

M Billaud

6

M

Billaud

1 reference

8 February 2023

D E Bredesen

7

D E

Bredesen

1 reference

8 February 2023

P Edery

8

P

Edery

1 reference

8 February 2023

P Mehlen

9

P

GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney

Mehlen

1 reference

8 February 2023

language of work or name

English

0 references

publication date

1 August 2000

0 references

published in

The EMBO Journal

0 references

volume

19

0 references

issue

15

0 references

page(s)

4056-63

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

X-linked IAP is a direct inhibitor of cell-death proteases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Neurturin, a relative of glial-cell-line-derived neurotrophic factor

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Mutations of the RET proto-oncogene in Hirschsprung's disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

ret transforming gene encodes a fusion protein homologous to tyrosine kinases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Crystal structure of baculovirus P35: role of a novel reactive site loop in apoptotic caspase inhibition

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Signaling through scaffold, anchoring, and adaptor proteins

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Regulation of cell death protease caspase-9 by phosphorylation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Biochemical characteristics of caspases-3, -6, -7, and -8

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Identification of Shc docking site on Ret tyrosine kinase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Activation of a novel human transforming gene, ret, by DNA rearrangement

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Renal agenesis and the absence of enteric neurons in mice lacking GDNF

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Cadherin cell adhesion receptors as a morphogenetic regulator

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Small stress protein Hsp27 accumulation during dopamine-mediated differentiation of rat olfactory neurons counteracts apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

p75NTR and the concept of cellular dependence: seeing how the other half die.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Various mechanisms cause RET-mediated signaling defects in Hirschsprung's disease.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Autoproteolytic activation of pro-caspases by oligomerization.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Caspases: intracellular signaling by proteolysis

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Induction of apoptosis by the low-affinity NGF receptor

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306592

Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity

30 May 2018

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2F19.15.4056

Loss of function effect of RET mutations causing Hirschsprung disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2F19.15.4056

Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2F19.15.4056

Distinct biological properties of two RET isoforms activated by MEN 2A and MEN 2B mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2F19.15.4056

RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10921886