MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain (Q22254196)

MCL1 apoptosis regulator, BCL2 family member

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tumor protein p53

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protein heterodimerization activity

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Journal of Biological Chemistry

J Bae

1

J

Bae

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29 March 2023

C P Leo

series ordinal

2

author given names

C P

author last names

Leo

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29 March 2023

S Y Hsu

series ordinal

3

author given names

S Y

author last names

Hsu

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29 March 2023

A J Hsueh

series ordinal

4

author given names

A J

author last names

Hsueh

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29 March 2023

language of work or name

English

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publication date

18 August 2000

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published in

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volume

275

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issue

33

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page(s)

25255-61

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cites work

Apoptosis in the pathogenesis and treatment of disease

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21 January 2018

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Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

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Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

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Overexpression of the human BCL-2 gene product results in growth enhancement of Epstein-Barr virus-immortalized B cells

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

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Structure—Function Analysis of Bcl-2 Family Proteins

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The Bcl-2 protein family: arbiters of cell survival

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

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Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

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MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

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The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

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Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma

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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

21 January 2018

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The BH3 domain of Bcl-x(S) is required for inhibition of the antiapoptotic function of Bcl-x(L).

21 January 2018

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A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells

21 January 2018

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Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members

21 January 2018

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Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

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Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary

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Inhibition of Bax channel-forming activity by Bcl-2

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Channel formation by antiapoptotic protein Bcl-2.

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Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins

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Prevention of apoptosis by a baculovirus gene during infection of insect cells

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BCL-2 family members and the mitochondria in apoptosis

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Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria?

21 January 2018

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BID: a novel BH3 domain-only death agonist

21 January 2018

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

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A splicing variant of the Bcl-2 member Bok with a truncated BH3 domain induces apoptosis but does not dimerize with antiapoptotic Bcl-2 proteins in vitro

21 January 2018

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A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells

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Bim: a novel member of the Bcl-2 family that promotes apoptosis

21 January 2018

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Mapping of the human BAX gene to chromosome 19q13.3-q13.4 and isolation of a novel alternatively spliced transcript, BAX delta.

21 January 2018

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A novel splice variant of the cell death-promoting protein BAX.

21 January 2018

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harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)

21 January 2018

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Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist

21 January 2018

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Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence

21 January 2018

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The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9

21 January 2018

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Caenorhabditis elegans EGL-1 disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation

21 January 2018

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Interference of BAD (Bcl-xL/Bcl-2-Associated Death Promoter)-Induced Apoptosis in Mammalian Cells by 14-3-3 Isoforms and P11

21 January 2018

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Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.

21 January 2018

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BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity

21 January 2018

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Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

21 January 2018

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Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

21 January 2018

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mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response

21 January 2018

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The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M909826199

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Consolidated OpenCitations Corpus – April 2017

3296540

3296540

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference