Ryanodine receptor 1, skeletal muscle (Q21980348)

RyR/IP3 receptor binding core, RIH domain superfamily

1 reference

Concanavalin A-like lectin/glucanase domain superfamily

1 reference

Mir domain superfamily

1 reference

EF-hand domain pair

1 reference

EF-hand domain, protein family

1 reference

Inositol 1,4,5-trisphosphate/ryanodine receptor domain, protein family

1 reference

B30.2/SPRY domain, protein family

1 reference

Ryanodine receptor Ryr, protein family

1 reference

Ryanodine receptor, SPRY domain 3, protein family

1 reference

Ryanodine Receptor TM 4-6, protein family

1 reference

Ion transport domain, protein family

1 reference

Ryanodine receptor, SPRY domain 1, protein family

1 reference

Ryanodine receptor, SPRY domain 2, protein family

1 reference

MIR motif domain, protein family

1 reference

SPRY domain, protein family

1 reference

RyR/IP3R Homology associated domain, protein family

1 reference

RIH domain, protein family

1 reference

voltage-gated calcium channel activity

1 reference

25 May 2022

1 reference

25 May 2022

An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line

calcium channel activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

1 reference

14 February 2019

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

1 reference

14 February 2019

Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

calcium-release channel activity

IPI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

3 references

14 February 2019

Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

Bioinformatics and cellular signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

ryanodine-sensitive calcium-release channel activity

IPI

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=E9PZQ0&geneProductId=UniProtKB:E9PZQ0

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=E9PZQ0&geneProductId=UniProtKB:E9PZQ0

24 April 2018

Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=E9PZQ0&geneProductId=UniProtKB:E9PZQ0

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=E9PZQ0&geneProductId=UniProtKB:E9PZQ0

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=E9PZQ0&geneProductId=UniProtKB:E9PZQ0

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

ryanodine-sensitive calcium-release channel activity

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

calcium-induced calcium release activity

3 references

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

integral component of membrane

2 references

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

Tissue-specific and developmentally regulated alternative splicing in mouse skeletal muscle ryanodine receptor mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

4 references

14 February 2019

Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

The Ca2+ channel alpha2delta-1 subunit determines Ca2+ current kinetics in skeletal muscle but not targeting of alpha1S or excitation-contraction coupling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin-proteasome pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

smooth endoplasmic reticulum

1 reference

24 April 2018

Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons

http://www.ebi.ac.uk/QuickGO/annotations?protein=E9PZQ0&geneProductId=UniProtKB:E9PZQ0

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

junctional membrane complex

1 reference

14 February 2019

Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

integral component of organelle membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

ryanodine receptor complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

sarcoplasmic reticulum membrane

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=E9PZQ0&geneProductId=UniProtKB:E9PZQ0

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=E9PZQ0&geneProductId=UniProtKB:E9PZQ0

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=E9PZQ0&geneProductId=UniProtKB:E9PZQ0

24 April 2018

An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line

http://www.ebi.ac.uk/QuickGO/annotations?protein=E9PZQ0&geneProductId=UniProtKB:E9PZQ0

24 April 2018

FKBP12.6 and cADPR regulation of Ca2+release in smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=E9PZQ0&geneProductId=UniProtKB:E9PZQ0

protein-containing complex

1 reference

14 February 2019

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

2 references

sarcoplasmic reticulum

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

Tissue-specific and developmentally regulated alternative splicing in mouse skeletal muscle ryanodine receptor mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

Ca2+ influx through alpha1S DHPR may play a role in regulating Ca2+ release from RyR1 in skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

The Ca2+ channel alpha2delta-1 subunit determines Ca2+ current kinetics in skeletal muscle but not targeting of alpha1S or excitation-contraction coupling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

extrinsic component of cytoplasmic side of plasma membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=E9PZQ0&geneProductId=UniProtKB:E9PZQ0

3 references

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

cytoplasmic vesicle membrane

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

sarcoplasmic reticulum membrane

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

FKBP12.6 and cADPR regulation of Ca2+release in smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

calcium channel complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

regulation of muscle contraction

biological process

1 reference

14 February 2019

Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

ossification involved in bone maturation

TAS

1 reference

14 February 2019

An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

outflow tract morphogenesis

1 reference

14 February 2019

An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

cellular calcium ion homeostasis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

2 references

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

skeletal muscle fiber development

1 reference

14 February 2019

An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

calcium ion transmembrane transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

2 references

transmembrane transport

1 reference

14 February 2019

1 reference

14 February 2019

An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

protein homotetramerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

cellular response to calcium ion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

cellular response to caffeine

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

release of sequestered calcium ion into cytosol

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=E9PZQ0&geneProductId=UniProtKB:E9PZQ0

24 April 2018

FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes

http://www.ebi.ac.uk/QuickGO/annotations?protein=E9PZQ0&geneProductId=UniProtKB:E9PZQ0

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=E9PZQ0&geneProductId=UniProtKB:E9PZQ0

3 references

14 February 2019

Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine-receptor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

Ca2+ influx through alpha1S DHPR may play a role in regulating Ca2+ release from RyR1 in skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

calcium ion transport

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

Ca2+ influx through alpha1S DHPR may play a role in regulating Ca2+ release from RyR1 in skeletal muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

regulation of cytosolic calcium ion concentration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

sarcoplasmic reticulum calcium ion transport

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

cellular response to ATP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

release of sequestered calcium ion into cytosol

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9PZQ0

has part(s)

Ryanodine receptor Ryr

1 reference

SPRY domain

1 reference

RIH domain

1 reference

B30.2/SPRY domain

1 reference

Inositol 1,4,5-trisphosphate/ryanodine receptor domain

1 reference

MIR motif

1 reference

Ion transport domain

1 reference

EF-hand domain

1 reference

Ryanodine Receptor TM 4-6

1 reference

RyR/IP3R Homology associated domain

1 reference

Ryanodine receptor, SPRY domain 3

1 reference

Ryanodine receptor, SPRY domain 2

1 reference

Ryanodine receptor, SPRY domain 1

1 reference