Cryptochrome 2 (photolyase-like) (Q21499186)

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mammalian protein found in Mus musculus
  • cryptochrome-2
  • Cry2
edit
Language Label Description Also known as
English
Cryptochrome 2 (photolyase-like)
mammalian protein found in Mus musculus
  • cryptochrome-2
  • Cry2

Statements

molecular function
protein binding
determination method
IPI
24 references
retrieved
8 April 2019
stated in
Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
CRY1/2 Selectively Repress PPARδ and Limit Exercise Capacity.
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
A novel protein, CHRONO, functions as a core component of the mammalian circadian clock
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
The polycomb group protein EZH2 is required for mammalian circadian clock function
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
Identification of two amino acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
Machine learning helps identify CHRONO as a circadian clock component
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
A novel protein, CHRONO, functions as a core component of the mammalian circadian clock
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
CAVIN-3 regulates circadian period length and PER:CRY protein abundance and interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
retrieved
8 April 2019
stated in
Identification of two amino acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IPI
cell component
biological process
negative regulation of transcription, DNA-templated
determination method
IDA
IGI
ISO
7 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
ISO
retrieved
14 February 2019
stated in
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IGI
retrieved
14 February 2019
stated in
CIPC is a mammalian circadian clock protein without invertebrate homologues
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IDA
retrieved
14 February 2019
stated in
Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IDA
retrieved
14 February 2019
stated in
Histone acetyltransferase-dependent chromatin remodeling and the vascular clock
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IDA
retrieved
14 February 2019
stated in
A novel protein, CHRONO, functions as a core component of the mammalian circadian clock
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IDA
retrieved
14 February 2019
stated in
Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IDA
negative regulation of transcription, DNA-templated
determination method
IDA
IGI
IMP
ISO
9 references
retrieved
8 April 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
ISO
retrieved
8 April 2019
stated in
CRY1/2 Selectively Repress PPARδ and Limit Exercise Capacity.
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IMP
retrieved
8 April 2019
stated in
Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IMP
retrieved
8 April 2019
stated in
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IGI
retrieved
8 April 2019
stated in
Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IDA
retrieved
8 April 2019
stated in
A novel protein, CHRONO, functions as a core component of the mammalian circadian clock
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IDA
retrieved
8 April 2019
stated in
CIPC is a mammalian circadian clock protein without invertebrate homologues
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IDA
retrieved
8 April 2019
stated in
Histone acetyltransferase-dependent chromatin remodeling and the vascular clock
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IDA
retrieved
8 April 2019
stated in
Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2
GOA
curator
UniProt
UniProt protein ID
Q9R194
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9R194
determination method
IDA

Identifiers

 
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