Engineering proteinase K using machine learning and synthetic genes (Q21256657)

18 August 2022

Jun Liao

1

Jun

Liao

1 reference

18 August 2022

Manfred K Warmuth

2

Manfred K

Warmuth

1 reference

18 August 2022

Sridhar Govindarajan

3

Sridhar

Govindarajan

1 reference

18 August 2022

Jon E Ness

4

Jon E

Ness

1 reference

18 August 2022

Rebecca P Wang

5

Rebecca P

Wang

1 reference

18 August 2022

Jeremy Minshull

7

Jeremy

Minshull

1 reference

describes a project that uses

18 August 2022

language of work or name

English

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publication date

2007

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published in

BMC Biotechnology

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volume

7

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issue

1

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page(s)

16

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1 reference

Two-step total gene synthesis method

1 reference

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CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

19 March 2017

1 reference

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DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution

19 March 2017

1 reference

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Structural basis of thermostability. Analysis of stabilizing mutations in subtilisin BPN'

19 March 2017

1 reference

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Environmental genome shotgun sequencing of the Sargasso Sea

19 March 2017

1 reference

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Accurate multiplex gene synthesis from programmable DNA microchips

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1847811

Surveying a local fitness landscape of a protein with epistatic sites for the study of directed evolution

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1847811

19 March 2017

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Totally in vitro protein selection using mRNA-protein fusions and ribosome display

29 November 2018

1 reference

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DNA shuffling of a family of genes from diverse species accelerates directed evolution

19 March 2017

1 reference

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A Sanger/pyrosequencing hybrid approach for the generation of high-quality draft assemblies of marine microbial genomes

19 March 2017

1 reference

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Support vector machines in HTS data mining: Type I MetAPs inhibition study

12 September 2017

1 reference

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Predicting enzyme function from protein sequence.

12 September 2017

1 reference

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Total synthesis of long DNA sequences: synthesis of a contiguous 32-kb polyketide synthase gene cluster.

12 September 2017

1 reference

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Codon bias and heterologous protein expression

12 September 2017

1 reference

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Comparison of methods based on diversity and similarity for molecule selection and the analysis of drug discovery data

12 September 2017

1 reference

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Key substrate recognition residues in the active site of a plant cytochrome P450, CYP73A1. Homology guided site-directed mutagenesis.

12 September 2017

1 reference

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Synthetic shuffling expands functional protein diversity by allowing amino acids to recombine independently

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1847811

Chemical synthesis of poliovirus cDNA: generation of infectious virus in the absence of natural template

12 September 2017

1 reference

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Important structural features of 15-residue lactoferricin derivatives and methods for improvement of antimicrobial activity.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1847811

Protein engineering of subtilisin

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1847811

Directed evolution: the 'rational' basis for 'irrational' design.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1847811

Recent progress in biomolecular engineering

12 September 2017

1 reference

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A method to predict functional residues in proteins

12 September 2017

1 reference

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Total synthesis and cloning of a gene coding for the ribonuclease S protein

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1847811

Construction of synthetic genes using PCR after automated DNA synthesis of their entire top and bottom strands

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1847811

Quantitative sequence-activity models (QSAM)--tools for sequence design

12 September 2017

1 reference

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Substrate specificity of human pancreatic elastase 2.

27 September 2017

1 reference

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A simple, rapid, high-fidelity and cost-effective PCR-based two-step DNA synthesis method for long gene sequences

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1847811

Computational thermostabilization of an enzyme

27 September 2017

1 reference

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Peptide quantitative structure-activity relationships, a multivariate approach.

30 May 2018

1 reference

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Enzyme engineering for nonaqueous solvents: random mutagenesis to enhance activity of subtilisin E in polar organic media

30 May 2018

1 reference

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A probabilistic active support vector learning algorithm

30 May 2018

1 reference

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Computational design of a biologically active enzyme

29 November 2018

1 reference

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Systematic variation of amino acid substitutions for stringent assessment of pairwise covariation

29 November 2018

1 reference

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Active learning with support vector machines in the drug discovery process.

29 November 2018

1 reference

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Kinetic characterization and inhibition of the rat MAB elastase-2, an angiotensin I-converting serine protease

29 November 2018

1 reference

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A cross-section of the fitness landscape of dihydrofolate reductase

29 November 2018

1 reference

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From DNA sequence to improved functionality: using protein sequence comparisons to rapidly design a thermostable consensus phytase

29 November 2018

1 reference

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Design of active analogues of a 15-residue peptide using D-optimal design, QSAR and a combinatorial search algorithm.

29 November 2018

1 reference

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Are there two distinct research strategies for developing biologically active molecules: rational design and empirical selection?

29 November 2018

1 reference

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Identifiers

DOI

10.1186/1472-6750-7-16

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