Histone deacetylase 4 (Q21173206)

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mammalian protein found in Homo sapiens
  • histone deacetylase 4
  • HDAC4
  • histone deacetylase A
edit
Language Label Description Also known as
English
Histone deacetylase 4
mammalian protein found in Homo sapiens
  • histone deacetylase 4
  • HDAC4
  • histone deacetylase A

Statements

molecular function
protein binding
determination method
IPI
29 references
retrieved
8 April 2019
stated in
Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1
GOA
curator
UniProt
UniProt protein ID
P56524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases
GOA
curator
UniProt
UniProt protein ID
P56524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation
GOA
curator
UniProt
UniProt protein ID
P56524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock
GOA
curator
UniProt
UniProt protein ID
P56524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
Differential localization of HDAC4 orchestrates muscle differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
Epstein-Barr nuclear antigen leader protein coactivates transcription through interaction with histone deacetylase 4.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
PP2A regulates HDAC4 nuclear import
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
JNK-ATF-2 inhibits thrombomodulin (TM) expression by recruiting histone deacetylase4 (HDAC4) and forming a transcriptional repression complex in the TM promoter
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
The functional interactome landscape of the human histone deacetylase family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of BCL6-interacting proteins by tandem mass spectrometry
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of histone deacetylase 4 by binding of 14-3-3 proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IPI
cell component
nucleus
determination method
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P56524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IEA
retrieved
8 April 2019
stated in
Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the regulation of placental cell fusion
GOA
curator
UniProt
UniProt protein ID
P56524
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IDA
retrieved
8 April 2019
stated in
Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IDA
retrieved
8 April 2019
stated in
Epigenetic changes as a common trigger of muscle weakness in congenital myopathies
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IDA
retrieved
8 April 2019
stated in
Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IDA
biological process
negative regulation of transcription by RNA polymerase II
determination method
IDA
IGI
IEA
IMP
6 references
retrieved
8 April 2019
stated in
HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IMP
retrieved
8 April 2019
stated in
FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IMP
retrieved
8 April 2019
stated in
PC4 coactivates MyoD by relieving the histone deacetylase 4-mediated inhibition of myocyte enhancer factor 2C.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IGI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IEA
retrieved
8 April 2019
stated in
Class II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IDA
retrieved
8 April 2019
stated in
Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524
determination method
IDA

Identifiers

RefSeq protein ID
Freebase ID
/m/02kfjwf
0 references
PDB structure ID
 
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