mitogen-activated protein kinase kinase kinase 3 (Q21154917)

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mammalian protein found in Homo sapiens

MAP/ERK kinase kinase 3
MEKK 3
mitogen-activated protein kinase kinase kinase 3
MAPK/ERK kinase kinase 3
MEK kinase 3
MAP3K3

Language	Label	Description	Also known as
English	mitogen-activated protein kinase kinase kinase 3	mammalian protein found in Homo sapiens	MAP/ERK kinase kinase 3 MEKK 3 mitogen-activated protein kinase kinase kinase 3 MAPK/ERK kinase kinase 3 MEK kinase 3 MAP3K3

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99759

Mitogen-activated protein kinase kinase kinase 2/3, PB1 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PB1 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

2 references

protein binding

determination method

8 references

8 April 2019

TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

8 April 2019

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

8 April 2019

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

8 April 2019

Phosphorylation of serine 526 is required for MEKK3 activity, and association with 14-3-3 blocks dephosphorylation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

8 April 2019

Phosphorylation of the stress-activated protein kinase, MEKK3, at serine 166

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

8 April 2019

Phosphorylation of MEKK3 at threonine 294 promotes 14-3-3 association to inhibit nuclear factor kappaB activation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

8 April 2019

Structural Insights into the Molecular Recognition between Cerebral Cavernous Malformation 2 and Mitogen-Activated Protein Kinase Kinase Kinase 3

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

biological process

intracellular signal transduction

determination method

1 reference

8 April 2019

TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

protein phosphorylation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

positive regulation of p38MAPK cascade

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

protein autophosphorylation

determination method

1 reference

8 April 2019

TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

blood vessel development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method

1 reference

8 April 2019

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

regulation of mitotic cell cycle

determination method

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99759&geneProductId=UniProtKB:Q99759

determination method

stress-activated protein kinase signaling cascade

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

activation of protein kinase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

regulation of apoptotic process

determination method

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99759&geneProductId=UniProtKB:Q99759

determination method

determination method

1 reference

8 April 2019

Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

interleukin-1-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

positive regulation of cell proliferation in bone marrow

determination method

1 reference

8 April 2019

miR-188 promotes senescence of lineage-negative bone marrow cells by targeting MAP3K3 expression.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

positive regulation of cell migration involved in sprouting angiogenesis

determination method

1 reference

8 April 2019

miR-188 promotes senescence of lineage-negative bone marrow cells by targeting MAP3K3 expression.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

negative regulation of cellular senescence

determination method

1 reference

8 April 2019

miR-188 promotes senescence of lineage-negative bone marrow cells by targeting MAP3K3 expression.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

signal transduction

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99759

determination method

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99759

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99759

Mitogen-activated protein kinase kinase kinase 2/3, PB1 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99759

Identifiers

MeSH descriptor ID

subject named as

MAP Kinase Kinase Kinase 3

0 references

D08.811.913.696.620.682.700.559.300

0 references

D12.776.476.563.554.300

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000354485

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000354485

ENSP00000354927

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000354927

ENSP00000461988

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000461988

ENSP00000462086

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462086

ENSP00000462917

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462917

ENSP00000464130

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464130

ENSP00000464482

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464482

ENSP00000464532

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464532

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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