GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1 (Q21144926)

identical protein binding

1 reference

ADP-ribosylation factor GTPase activating protein 1

1 reference

Leucine-rich repeat kinase 2

1 reference

Creative Commons Attribution 4.0 International

0 references

Alzbeta Trancikova

2

Alzbeta

Trancikova

1 reference

17 August 2022

Andrew B West

5

Andrew B

West

1 reference

17 August 2022

4

Liliane

Glauser

Liliane Glauser

1 reference

17 August 2022

1

Klodjan

Stafa

Klodjan Stafa

1 reference

17 August 2022

Philip J Webber

3

Philip J

Webber

1 reference

17 August 2022

Darren J Moore

series ordinal

6

author given names

Darren J

author last names

Moore

1 reference

17 August 2022

language of work or name

English

0 references

publication date

2012

0 references

published in

PLOS Genetics

0 references

volume

8

0 references

issue

2

0 references

page(s)

e1002526

0 references

copyright license

start time

9 February 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3280333/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation

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The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

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The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration

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LRRK2 regulates synaptic vesicle endocytosis

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Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

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The R1441C mutation of LRRK2 disrupts GTP hydrolysis

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GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

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Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

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Localization of LRRK2 to membranous and vesicular structures in mammalian brain

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

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Kinase activity of mutant LRRK2 mediates neuronal toxicity

19 March 2017

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Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

19 March 2017

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The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

19 March 2017

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

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ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat

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Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

19 March 2017

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A phosphatidylinositol-3-kinase-dependent signal transition regulates ARF1 and ARF6 during Fcgamma receptor-mediated phagocytosis

19 March 2017

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SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

19 March 2017

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

7 April 2017

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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

7 April 2017

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LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

7 April 2017

1 reference

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LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

12 September 2017

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Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities

12 September 2017

1 reference

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12 September 2017

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ARFGAP1 promotes AP-2-dependent endocytosis.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics.

12 September 2017

1 reference

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Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

12 September 2017

1 reference

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Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

GTPase activity plays a key role in the pathobiology of LRRK2.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

Identification of the autophosphorylation sites of LRRK2.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

Mendelian forms of Parkinson's disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

The Roco protein family: a functional perspective

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

Parkin mediates the degradation-independent ubiquitination of Hsp70

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

Dynamic and redundant regulation of LRRK2 and LRRK1 expression

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

Insights into COPI coat assembly and function in living cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

ArfGAP1 dynamics and its role in COPI coat assembly on Golgi membranes of living cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

COP and clathrin-coated vesicle budding: different pathways, common approaches

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

Apoptotic mechanisms in mutant LRRK2-mediated cell death

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

Two distinct members of the ADP-ribosylation factor family of GTP-binding proteins regulate cell-free intra-Golgi transport

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3280333

LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.

30 May 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002526

Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002526

A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002526

Golgi localization determinants in ArfGAP1 and in new tissue-specific ArfGAP1 isoforms

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002526

Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002526

Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002526

ArfGAP1 activity and COPI vesicle biogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002526

LRRK2G2019S as a Cause of Parkinson's Disease in North African Arabs

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002526

Biochemical Fractionation of Brain Tissue for Studies of Receptor Distribution and Trafficking

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22363216

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The Parkinson disease gene LRRK2: evolutionary and structural insights

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22363216

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PGEN.1002526

1 reference

1668953

1668953

1 reference

1 reference

1 reference