tripeptidyl peptidase 1 (Q21136439)

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mammalian protein found in Homo sapiens

TPP1
TPP-I
cell growth-inhibiting gene 1 protein
lysosomal pepstatin-insensitive carboxypeptidase
Tripeptidyl-peptidase I
tripeptidyl-peptidase 1
lysosomal pepstatin insensitive protease
growth-inhibiting protein 1
tripeptidyl aminopeptidase
tripeptidyl peptidase I
Lysosomal pepstatin-insensitive protease
LPIC

Language	Label	Description	Also known as
English	tripeptidyl peptidase 1	mammalian protein found in Homo sapiens	TPP1 TPP-I cell growth-inhibiting gene 1 protein lysosomal pepstatin-insensitive carboxypeptidase Tripeptidyl-peptidase I tripeptidyl-peptidase 1 lysosomal pepstatin insensitive protease growth-inhibiting protein 1 tripeptidyl aminopeptidase tripeptidyl peptidase I Lysosomal pepstatin-insensitive protease LPIC

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

Peptidase S8/S53 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14773

Peptidase S53, activation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Sedolisin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

tripeptidyl-peptidase activity

determination method

5 references

17 October 2017

Characterization of endopeptidase activity of tripeptidyl peptidase-I/CLN2 protein which is deficient in classical late infantile neuronal ceroid lipofuscinosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773

determination method

17 October 2017

Purification and characterization of bovine brain lysosomal pepstatin-insensitive proteinase, the gene product deficient in the human late-infantile neuronal ceroid lipofuscinosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773

determination method

17 October 2017

The human CLN2 protein/tripeptidyl-peptidase I is a serine protease that autoactivates at acidic pH

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773

determination method

17 October 2017

Tripeptidyl peptidase I, the late infantile neuronal ceroid lipofuscinosis gene product, initiates the lysosomal degradation of subunit c of ATP synthase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773

determination method

17 October 2017

Neuronal ceroid lipofuscinoses are connected at molecular level: interaction of CLN5 protein with CLN2 and CLN3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773

determination method

peptide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

endopeptidase activity

determination method

2 references

17 October 2017

Characterization of endopeptidase activity of tripeptidyl peptidase-I/CLN2 protein which is deficient in classical late infantile neuronal ceroid lipofuscinosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773

determination method

17 October 2017

Tripeptidyl peptidase I, the late infantile neuronal ceroid lipofuscinosis gene product, initiates the lysosomal degradation of subunit c of ATP synthase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

protein binding

determination method

4 references

8 April 2019

Neuronal ceroid lipofuscinoses are connected at molecular level: interaction of CLN5 protein with CLN2 and CLN3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

serine-type peptidase activity

determination method

3 references

8 April 2019

The human CLN2 protein/tripeptidyl-peptidase I is a serine protease that autoactivates at acidic pH

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

serine-type endopeptidase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

endopeptidase activity

determination method

3 references

8 April 2019

Characterization of endopeptidase activity of tripeptidyl peptidase-I/CLN2 protein which is deficient in classical late infantile neuronal ceroid lipofuscinosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

Tripeptidyl peptidase I, the late infantile neuronal ceroid lipofuscinosis gene product, initiates the lysosomal degradation of subunit c of ATP synthase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

tripeptidyl-peptidase activity

determination method

6 references

8 April 2019

Characterization of endopeptidase activity of tripeptidyl peptidase-I/CLN2 protein which is deficient in classical late infantile neuronal ceroid lipofuscinosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

Purification and characterization of bovine brain lysosomal pepstatin-insensitive proteinase, the gene product deficient in the human late-infantile neuronal ceroid lipofuscinosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

Neuronal ceroid lipofuscinoses are connected at molecular level: interaction of CLN5 protein with CLN2 and CLN3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

The human CLN2 protein/tripeptidyl-peptidase I is a serine protease that autoactivates at acidic pH

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

Tripeptidyl peptidase I, the late infantile neuronal ceroid lipofuscinosis gene product, initiates the lysosomal degradation of subunit c of ATP synthase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

lysosomal lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

determination method

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773

determination method

determination method

5 references

8 April 2019

Association of mutations in a lysosomal protein with classical late-infantile neuronal ceroid lipofuscinosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

Mutations in classical late infantile neuronal ceroid lipofuscinosis disrupt transport of tripeptidyl-peptidase I to lysosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

extracellular exosome

determination method

3 references

17 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773

determination method

17 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773

determination method

17 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773

determination method

biological process

epithelial cell differentiation

determination method

1 reference

8 April 2019

Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

lipid metabolism

determination method

1 reference

8 April 2019

Association of mutations in a lysosomal protein with classical late-infantile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

bone resorption

determination method

1 reference

8 April 2019

Purification and characterization of a tripeptidyl peptidase I from human osteoclastomas: evidence for its role in bone resorption

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

nervous system development

determination method

1 reference

8 April 2019

Association of mutations in a lysosomal protein with classical late-infantile neuronal ceroid lipofuscinosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

determination method

4 references

17 October 2017

Tripeptidyl peptidase I, the late infantile neuronal ceroid lipofuscinosis gene product, initiates the lysosomal degradation of subunit c of ATP synthase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773

determination method

17 October 2017

Association of mutations in a lysosomal protein with classical late-infantile neuronal ceroid lipofuscinosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773

determination method

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773

determination method

central nervous system development

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

IRE1-mediated unfolded protein response

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

protein catabolic process

determination method

1 reference

8 April 2019

Batten's disease: clues to neuronal protein catabolism in lysosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

peptide catabolic process

determination method

2 references

8 April 2019

Classical late infantile neuronal ceroid lipofuscinosis fibroblasts are deficient in lysosomal tripeptidyl peptidase I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

The lysosomal degradation of neuromedin B is dependent on tripeptidyl peptidase-I: evidence for the impairment of neuropeptide degradation in late-infantile neuronal ceroid lipofuscinosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

determination method

5 references

8 April 2019

Association of mutations in a lysosomal protein with classical late-infantile neuronal ceroid lipofuscinosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

Tripeptidyl peptidase I, the late infantile neuronal ceroid lipofuscinosis gene product, initiates the lysosomal degradation of subunit c of ATP synthase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773

determination method

Sedolisin domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14773

Peptidase S53, activation domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14773

Identifiers

MeSH descriptor ID

subject named as

Tripeptidyl-Peptidase 1

0 references

D08.811.277.656.350.100.877

0 references

D08.811.277.656.350.350.843

0 references

D08.811.277.656.959.780

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000299427

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000299427

ENSP00000437066

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000437066

ENSP00000398136

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000398136

ENSP00000434647

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000434647

ENSP00000435001

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000435001

ENSP00000495893

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495893

ENSP00000494324

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494324

ENSP00000495895

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495895

ENSP00000495058

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495058

ENSP00000495849

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495849

ENSP00000496133

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496133

ENSP00000494085

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494085

ENSP00000494165

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494165

ENSP00000493574

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000493574

ENSP00000493706

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000493706

ENSP00000495558

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495558

ENSP00000493657

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000493657

ENSP00000496372

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496372

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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