SPT5 homolog, DSIF elongation factor subunit (Q21134455)

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mammalian protein found in Homo sapiens

DRB sensitivity-inducing factor large subunit
suppressor of Ty 5 homolog
Tat-CT1 protein
SUPT5H
transcription elongation factor SPT5
hSPT5
DRB sensitivity-inducing factor 160 kDa subunit
DSIF p160
Tat-cotransactivator 1 protein
DSIF large subunit

Language	Label	Description	Also known as
English	SPT5 homolog, DSIF elongation factor subunit	mammalian protein found in Homo sapiens	DRB sensitivity-inducing factor large subunit suppressor of Ty 5 homolog Tat-CT1 protein SUPT5H transcription elongation factor SPT5 hSPT5 DRB sensitivity-inducing factor 160 kDa subunit DSIF p160 Tat-cotransactivator 1 protein DSIF large subunit

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

12 references

8 April 2019

GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

8 April 2019

A human protein-protein interaction network: a resource for annotating the proteome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

8 April 2019

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

8 April 2019

Structure and function of the human transcription elongation factor DSIF

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

8 April 2019

Identification of a regulator of transcription elongation as an accessory factor for the human Mediator coactivator.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

8 April 2019

Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

8 April 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

8 April 2019

Structure of transcribing mammalian RNA polymerase II

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

8 April 2019

Human nuclear Dicer restricts the deleterious accumulation of endogenous double-stranded RNA.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

8 April 2019

Pooled-matrix protein interaction screens using Barcode Fusion Genetics

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

protein heterodimerization activity

determination method

1 reference

8 April 2019

DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

determination method

1 reference

8 April 2019

Structure and function of the human transcription elongation factor DSIF

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

chromatin binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00267&geneProductId=UniProtKB:O00267

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

determination method

1 reference

17 October 2017

DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00267&geneProductId=UniProtKB:O00267

determination method

biological process

chromatin remodeling

determination method

1 reference

17 October 2017

Structure and function of the human transcription elongation factor DSIF

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00267&geneProductId=UniProtKB:O00267

determination method

negative regulation of mRNA polyadenylation

determination method

1 reference

8 April 2019

CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00267&geneProductId=UniProtKB:O00267

determination method

transcription elongation from RNA polymerase II promoter

determination method

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00267&geneProductId=UniProtKB:O00267

determination method

17 October 2017

DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00267&geneProductId=UniProtKB:O00267

determination method

17 October 2017

Structure and function of the human transcription elongation factor DSIF

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00267&geneProductId=UniProtKB:O00267

determination method

regulation of DNA-templated transcription, elongation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

negative regulation of transcription by RNA polymerase II

determination method

7-methylguanosine mRNA capping

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

transcription by RNA polymerase II

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

response to organic substance

determination method

1 reference

17 October 2017

Structure and function of the human transcription elongation factor DSIF

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00267&geneProductId=UniProtKB:O00267

determination method

transcription, DNA-templated

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00267&geneProductId=UniProtKB:O00267

determination method

negative regulation of DNA-templated transcription, elongation

determination method

positive regulation of DNA-templated transcription, elongation

determination method

1 reference

8 April 2019

DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

positive regulation of macroautophagy

determination method

1 reference

8 April 2019

Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

DNA-templated transcription, elongation

determination method

1 reference

17 October 2017

Structure and function of the human transcription elongation factor DSIF

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00267&geneProductId=UniProtKB:O00267

determination method

single stranded viral RNA replication via double stranded DNA intermediate

determination method

1 reference

17 October 2017

Structure and function of the human transcription elongation factor DSIF

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00267&geneProductId=UniProtKB:O00267

determination method

positive regulation of viral transcription

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

determination method

1 reference

17 October 2017

Structure and function of the human transcription elongation factor DSIF

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00267&geneProductId=UniProtKB:O00267

determination method

negative regulation of transcription by RNA polymerase II

determination method

transcription elongation from RNA polymerase II promoter

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

8 April 2019

Structure and function of the human transcription elongation factor DSIF

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

8 April 2019

DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00267

determination method

negative regulation of DNA-templated transcription, elongation

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000352117

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000352117

ENSP00000384505

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000384505

ENSP00000404029

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000404029

ENSP00000469090

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000469090

ENSP00000470252

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000470252

ENSP00000469915

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000469915

ENSP00000470595

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000470595

ENSP00000471561

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000471561

ENSP00000472675

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000472675

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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