Troponin C1, slow skeletal and cardiac type (Q21124649)

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mammalian protein found in Homo sapiens

troponin C, slow skeletal and cardiac muscles
cardiac troponin C
TNNC1
troponin C type 1 (slow)
slow twitch skeletal/cardiac muscle troponin C

Language	Label	Description	Also known as
English	Troponin C1, slow skeletal and cardiac type	mammalian protein found in Homo sapiens	troponin C, slow skeletal and cardiac muscles cardiac troponin C TNNC1 troponin C type 1 (slow) slow twitch skeletal/cardiac muscle troponin C

Statements

1 reference

13 November 2019

UniProt protein ID

EF-hand domain pair

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63316

EF-hand domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EF-Hand 1, calcium-binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

calcium ion binding

determination method

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63316&geneProductId=UniProtKB:P63316

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63316&geneProductId=UniProtKB:P63316

determination method

27 March 2018

Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63316&geneProductId=UniProtKB:P63316

determination method

27 March 2018

Tryptophan mutants of cardiac troponin C: 3D structure, troponin I affinity, and in situ activity

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63316&geneProductId=UniProtKB:P63316

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

Tryptophan mutants of cardiac troponin C: 3D structure, troponin I affinity, and in situ activity

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

troponin T binding

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

calcium-dependent protein binding

determination method

1 reference

27 March 2018

Overexpression of human cardiac troponin-I and troponin-C in Escherichia coli and their purification and characterisation. Two point mutations allow high-level expression of troponin-I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63316&geneProductId=UniProtKB:P63316

determination method

protein binding

determination method

4 references

8 April 2019

Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

8 April 2019

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

8 April 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

8 April 2019

Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

troponin I binding

determination method

4 references

8 April 2019

Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

8 April 2019

Overexpression of human cardiac troponin-I and troponin-C in Escherichia coli and their purification and characterisation. Two point mutations allow high-level expression of troponin-I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

8 April 2019

Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

8 April 2019

Tryptophan mutants of cardiac troponin C: 3D structure, troponin I affinity, and in situ activity

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

actin filament binding

determination method

calcium ion binding

determination method

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

8 April 2019

Tryptophan mutants of cardiac troponin C: 3D structure, troponin I affinity, and in situ activity

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

8 April 2019

Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

calcium-dependent protein binding

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

troponin complex

determination method

2 references

27 March 2018

Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63316&geneProductId=UniProtKB:P63316

determination method

27 March 2018

Cardiac troponin T isoforms affect the Ca2+ sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63316&geneProductId=UniProtKB:P63316

determination method

contractile fiber

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

cardiac Troponin complex

determination method

1 reference

8 April 2019

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

troponin complex

determination method

3 references

8 April 2019

Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

8 April 2019

Cardiac troponin T isoforms affect the Ca2+ sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

biological process

regulation of muscle contraction

determination method

transition between fast and slow fiber

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

diaphragm contraction

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

response to metal ion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

ventricular cardiac muscle tissue morphogenesis

determination method

1 reference

8 April 2019

Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

muscle filament sliding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

skeletal muscle contraction

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

cardiac muscle contraction

determination method

3 references

8 April 2019

Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

8 April 2019

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

regulation of muscle contraction

determination method

3 references

8 April 2019

Cloning, structural analysis, and expression of the human slow twitch skeletal muscle/cardiac troponin C gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

8 April 2019

Tryptophan mutants of cardiac troponin C: 3D structure, troponin I affinity, and in situ activity

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63316

determination method

physically interacts with

object has role

positive modulator

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2051955

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63316

EF-hand 1, calcium-binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63316

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000232975

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000232975

ENSP00000420596

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000420596

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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