Phosphodiesterase 3A (Q21123247)

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mammalian protein found in Homo sapiens

CGI-PDE A
cGMP-inhibited 3',5'-cyclic phosphodiesterase A
cyclic GMP-inhibited phosphodiesterase A
cAMP phosphodiesterase, myocardial cGMP-inhibited
phosphodiesterase 3A, cGMP-inhibited
PDE3A

Language	Label	Description	Also known as
English	Phosphodiesterase 3A	mammalian protein found in Homo sapiens	CGI-PDE A cGMP-inhibited 3',5'-cyclic phosphodiesterase A cyclic GMP-inhibited phosphodiesterase A cAMP phosphodiesterase, myocardial cGMP-inhibited phosphodiesterase 3A, cGMP-inhibited PDE3A

Statements

1 reference

13 November 2019

UniProt protein ID

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14432

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

HD/PDEase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

determination method

determination method

1 reference

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

determination method

phosphoric diester hydrolase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

determination method

3',5'-cyclic-GMP phosphodiesterase activity

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

determination method

protein binding

determination method

1 reference

8 April 2019

Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

determination method

cGMP-inhibited cyclic-nucleotide phosphodiesterase activity

determination method

1 reference

8 April 2019

Expression and mutagenesis of the catalytic domain of cGMP-inhibited phosphodiesterase (PDE3) cloned from human platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

determination method

3',5'-cyclic-AMP phosphodiesterase activity

determination method

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

determination method

determination method

2 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

determination method

determination method

biological process

negative regulation of apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

determination method

regulation of meiotic nuclear division

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

determination method

lipid metabolism

determination method

1 reference

8 April 2019

Molecular cloning and chromosomal assignment of the human homologue of the rat cGMP-inhibited phosphodiesterase 1 (PDE3A)--a gene involved in fat metabolism located at 11p 15.1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

determination method

cGMP-mediated signaling

determination method

1 reference

10 September 2018

Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

determination method

signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

determination method

response to cAMP

determination method

1 reference

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

determination method

cAMP-mediated signaling

determination method

1 reference

10 September 2018

Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

determination method

cellular response to transforming growth factor beta stimulus

determination method

1 reference

8 April 2019

Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

determination method

positive regulation of vascular permeability

determination method

1 reference

8 April 2019

Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

determination method

oocyte maturation

determination method

1 reference

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

determination method

positive regulation of oocyte development

determination method

1 reference

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

determination method

diterpenoid metabolic process

determination method

1 reference

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

determination method

negative regulation of vascular permeability

determination method

1 reference

8 April 2019

Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

determination method

cellular response to cGMP

determination method

1 reference

8 April 2019

Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

determination method

cAMP catabolic process

determination method

3 references

5 June 2018

Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

determination method

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

determination method

5 June 2018

Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

determination method

G protein-coupled receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

determination method

negative regulation of cAMP-mediated signaling

determination method

3 references

8 April 2019

Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

determination method

physically interacts with

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

guanosine cyclic 3',5'-phosphate

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1752

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2051955

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL799

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL19449

3'5'-cyclic nucleotide phosphodiesterase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14432

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14432

HD/PDEase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14432

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

7 March 2020

1 reference

7 March 2020

1 reference

7 March 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000351957

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000351957

PDB structure ID

1 reference

15 November 2015

http://www.uniprot.org/uniprot/Q14432.txt?version=148

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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