Phosphodiesterase 3B (Q21123244)

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mammalian protein found in Homo sapiens

phosphodiesterase 3B, cGMP-inhibited
cyclic GMP-inhibited phosphodiesterase B
CGIPDE1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B
PDE3B
cyclic nucleotide phosphodiesterase
CGIP1
CGI-PDE B

Language	Label	Description	Also known as
English	Phosphodiesterase 3B	mammalian protein found in Homo sapiens	phosphodiesterase 3B, cGMP-inhibited cyclic GMP-inhibited phosphodiesterase B CGIPDE1 cGMP-inhibited 3',5'-cyclic phosphodiesterase B PDE3B cyclic nucleotide phosphodiesterase CGIP1 CGI-PDE B

Statements

1 reference

13 November 2019

UniProt protein ID

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13370

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

HD/PDEase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

cGMP-inhibited cyclic-nucleotide phosphodiesterase activity

determination method

1 reference

8 April 2019

Characterization of the cDNA and gene encoding human PDE3B, the cGIP1 isoform of the human cyclic GMP-inhibited cyclic nucleotide phosphodiesterase family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

protein kinase B binding

determination method

1 reference

31 October 2017

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13370&geneProductId=UniProtKB:Q13370

determination method

protein binding

determination method

2 references

8 April 2019

A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

8 April 2019

Protein kinase A phosphorylation of human phosphodiesterase 3B promotes 14-3-3 protein binding and inhibits phosphatase-catalyzed inactivation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

phosphoric diester hydrolase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

3',5'-cyclic-nucleotide phosphodiesterase activity

determination method

5 references

8 April 2019

Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

8 April 2019

Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

8 April 2019

Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

3',5'-cyclic-AMP phosphodiesterase activity

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13370&geneProductId=UniProtKB:Q13370

determination method

3',5'-cyclic-GMP phosphodiesterase activity

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13370&geneProductId=UniProtKB:Q13370

determination method

3',5'-cyclic-AMP phosphodiesterase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

Golgi apparatus

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

determination method

3 references

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13370&geneProductId=UniProtKB:Q13370

determination method

31 October 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13370&geneProductId=UniProtKB:Q13370

determination method

31 October 2017

Phosphodiesterase 3 is present in rabbit and human erythrocytes and its inhibition potentiates iloprost-induced increases in cAMP

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13370&geneProductId=UniProtKB:Q13370

determination method

endoplasmic reticulum

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

guanyl-nucleotide exchange factor complex

determination method

1 reference

8 April 2019

Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

8 April 2019

Phosphodiesterase 3 is present in rabbit and human erythrocytes and its inhibition potentiates iloprost-induced increases in cAMP

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

8 April 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

biological process

negative regulation of cell adhesion

determination method

1 reference

8 April 2019

Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

cAMP catabolic process

determination method

2 references

31 October 2017

Phosphodiesterase 3 is present in rabbit and human erythrocytes and its inhibition potentiates iloprost-induced increases in cAMP

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13370&geneProductId=UniProtKB:Q13370

determination method

31 October 2017

Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13370&geneProductId=UniProtKB:Q13370

determination method

negative regulation of cAMP-mediated signaling

determination method

1 reference

31 October 2017

Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13370&geneProductId=UniProtKB:Q13370

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

cellular response to insulin stimulus

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

negative regulation of angiogenesis

determination method

1 reference

8 April 2019

A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

negative regulation of lipid catabolic process

determination method

1 reference

8 April 2019

Mechanism of intracellular calcium ([Ca2+]i) inhibition of lipolysis in human adipocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

negative regulation of cell adhesion mediated by integrin

determination method

1 reference

8 April 2019

Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

G protein-coupled receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

determination method

negative regulation of cAMP-mediated signaling

determination method

physically interacts with

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

guanosine cyclic 3',5'-phosphate

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2051955

3'5'-cyclic nucleotide phosphodiesterase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13370

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13370

HD/PDEase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13370

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000282096

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000282096

ENSP00000388644

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000388644

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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