General transcription factor IIF subunit 1 (Q21120536)

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mammalian protein found in Homo sapiens

GTF2F1
transcription initiation factor IIF subunit alpha
transcription initiation factor RAP74
general transcription factor IIF 74 kDa subunit
TFIIF-alpha
general transcription factor IIF, polypeptide 1, 74kDa
general transcription factor IIF subunit 1

Language	Label	Description	Also known as
English	General transcription factor IIF subunit 1	mammalian protein found in Homo sapiens	GTF2F1 transcription initiation factor IIF subunit alpha transcription initiation factor RAP74 general transcription factor IIF 74 kDa subunit TFIIF-alpha general transcription factor IIF, polypeptide 1, 74kDa general transcription factor IIF subunit 1

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

2 references

transcription coactivator activity

determination method

1 reference

8 April 2019

Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

transcription factor binding

determination method

1 reference

8 April 2019

TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

protein binding

determination method

11 references

8 April 2019

Transcription factor IIB acetylates itself to regulate transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

8 April 2019

Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

8 April 2019

Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

8 April 2019

RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

8 April 2019

Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

8 April 2019

A Novel RNA Polymerase II C-terminal Domain Phosphatase That Preferentially Dephosphorylates Serine 5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

8 April 2019

Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

8 April 2019

Novel dimerization fold of RAP30/RAP74 in human TFIIF at 1.7 A resolution

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

8 April 2019

Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP)

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

8 April 2019

Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

8 April 2019

FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

phosphatase activator activity

determination method

1 reference

8 April 2019

A Novel RNA Polymerase II C-terminal Domain Phosphatase That Preferentially Dephosphorylates Serine 5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

protein phosphatase binding

determination method

1 reference

8 April 2019

NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

protein domain specific binding

determination method

1 reference

8 April 2019

Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

RNA polymerase II general transcription initiation factor activity

determination method

1 reference

8 April 2019

Near-atomic resolution visualization of human transcription promoter opening

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

promoter-specific chromatin binding

determination method

1 reference

8 April 2019

A new paradigm for transcription factor TFIIB functionality

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

intracellular membrane-bounded organelle

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

transcription factor TFIIF complex

determination method

1 reference

8 April 2019

Characterization of cDNA for the large subunit of the transcription initiation factor TFIIF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

transcription factor TFIID complex

determination method

1 reference

8 April 2019

Near-atomic resolution visualization of human transcription promoter opening

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

determination method

4 references

8 April 2019

Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

protein-containing complex

determination method

1 reference

8 April 2019

NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

biological process

mRNA splicing, via spliceosome

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

regulation of transcription, DNA-templated

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35269&geneProductId=UniProtKB:P35269

determination method

transcription elongation from RNA polymerase II promoter

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

response to virus

determination method

1 reference

8 April 2019

Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

7-methylguanosine mRNA capping

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

transcription by RNA polymerase II

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

8 April 2019

Characterization of cDNA for the large subunit of the transcription initiation factor TFIIF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

8 April 2019

Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

transcription, DNA-templated

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35269&geneProductId=UniProtKB:P35269

determination method

positive regulation of viral transcription

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

transcription initiation from RNA polymerase II promoter

determination method

positive regulation of transcription elongation from RNA polymerase II promoter

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35269&geneProductId=UniProtKB:P35269

determination method

snRNA transcription by RNA polymerase II

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

fibroblast growth factor receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

positive regulation of catalytic activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

RNA metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

negative regulation of protein binding

determination method

1 reference

8 April 2019

RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35269

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000377969

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000377969

ENSP00000469091

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000469091

ENSP00000471403

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000471403

ENSP00000471542

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000471542

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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