Pyruvate dehydrogenase E1 subunit beta (Q21118903)

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mammalian protein found in Homo sapiens

pyruvate dehydrogenase E1 beta subunit
epididymis secretory sperm binding protein
pyruvate dehydrogenase E1 component subunit beta, mitochondrial
pyruvate dehydrogenase, E1 beta polypeptide
pyruvate dehydrogenase (lipoamide) beta
PDHB

Language	Label	Description	Also known as
English	Pyruvate dehydrogenase E1 subunit beta	mammalian protein found in Homo sapiens	pyruvate dehydrogenase E1 beta subunit epididymis secretory sperm binding protein pyruvate dehydrogenase E1 component subunit beta, mitochondrial pyruvate dehydrogenase, E1 beta polypeptide pyruvate dehydrogenase (lipoamide) beta PDHB

Statements

1 reference

13 November 2019

UniProt protein ID

Thiamin diphosphate-binding fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11177

Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11177

Transketolase-like, pyrimidine-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Transketolase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

pyruvate dehydrogenase activity

determination method

1 reference

9 May 2019

Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

protein binding

determination method

4 references

9 May 2019

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

9 May 2019

Binding of pyruvate dehydrogenase to the core of the human pyruvate dehydrogenase complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

9 May 2019

Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

9 May 2019

Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

catalytic activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

oxidoreductase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

pyruvate dehydrogenase (acetyl-transferring) activity

determination method

3 references

9 May 2019

Characterization of two cDNA clones for pyruvate dehydrogenase E1 beta subunit and its regulation in tricarboxylic acid cycle-deficient fibroblast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

pyruvate dehydrogenase (NAD+) activity

determination method

1 reference

9 May 2019

Mutations of the E1beta subunit gene (PDHB) in four families with pyruvate dehydrogenase deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

pyruvate dehydrogenase complex

determination method

1 reference

9 May 2019

Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

determination method

1 reference

9 May 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

extracellular exosome

determination method

1 reference

17 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11177&geneProductId=UniProtKB:P11177

determination method

determination method

1 reference

17 October 2017

Proteomic characterization of the human sperm nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11177&geneProductId=UniProtKB:P11177

determination method

determination method

1 reference

9 May 2019

Proteomic characterization of the human sperm nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

biological process

mitochondrial acetyl-CoA biosynthetic process from pyruvate

determination method

1 reference

9 May 2019

Mutations of the E1beta subunit gene (PDHB) in four families with pyruvate dehydrogenase deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

tricarboxylic acid cycle

determination method

3 references

9 May 2019

Characterization of two cDNA clones for pyruvate dehydrogenase E1 beta subunit and its regulation in tricarboxylic acid cycle-deficient fibroblast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

9 May 2019

Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

regulation of acetyl-CoA biosynthetic process from pyruvate

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11177&geneProductId=UniProtKB:P11177

determination method

pyruvate metabolic process

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

glucose metabolic process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11177&geneProductId=UniProtKB:P11177

determination method

cellular nitrogen compound metabolic process

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11177&geneProductId=UniProtKB:P11177

determination method

carbohydrate metabolic process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

acetyl-CoA biosynthetic process from pyruvate

determination method

1 reference

8 April 2019

Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11177

determination method

Transketolase, C-terminal domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11177

Transketolase-like, pyrimidine-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11177

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000307241

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000307241

ENSP00000373220

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000373220

ENSP00000417267

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417267

ENSP00000418448

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000418448

ENSP00000419580

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000419580

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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