Hyaluronidase 1 (Q21118410)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Homo sapiens

luCa-1
Hyaluronoglucosaminidase-1
tumor suppressor LUCA-1
HYAL1
plasma hyaluronidase
hyaluronidase-1
lung carcinoma protein 1
hyaluronoglucosaminidase 1

Language	Label	Description	Also known as
English	Hyaluronidase 1	mammalian protein found in Homo sapiens	luCa-1 Hyaluronoglucosaminidase-1 tumor suppressor LUCA-1 HYAL1 plasma hyaluronidase hyaluronidase-1 lung carcinoma protein 1 hyaluronoglucosaminidase 1

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12794

glycoside hydrolase superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12794

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12794

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transcription factor binding

determination method

1 reference

8 April 2019

Epigenetic regulation of HYAL-1 hyaluronidase expression. identification of HYAL-1 promoter

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

hydrolase activity, acting on glycosyl bonds

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

catalytic activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

hyaluronan synthase activity

determination method

1 reference

8 April 2019

Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

hyalurononglucosaminidase activity

determination method

14 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794

determination method

1 January 2018

Endocytosis of hyaluronidase-1 by the liver

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794

determination method

1 January 2018

Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794

determination method

1 January 2018

Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794

determination method

1 January 2018

Hyaluronidases and CD44 undergo differential modulation during chondrogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794

determination method

1 January 2018

HYAL1 overexpression is correlated with the malignant behavior of human breast cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794

determination method

1 January 2018

Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794

determination method

1 January 2018

Ultraviolet-B irradiation induces differential regulations of hyaluronidase expression and activity in normal human keratinocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794

determination method

1 January 2018

Purification, cloning, and expression of human plasma hyaluronidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794

determination method

1 January 2018

Designed human serum hyaluronidase 1 variant, HYAL1DeltaL, exhibits activity up to pH 5.9

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794

determination method

1 January 2018

Subtype specific elevated expression of hyaluronidase-1 (HYAL-1) in epithelial ovarian cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794

determination method

1 January 2018

CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794

determination method

hyalurononglucosaminidase activity

determination method

13 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

Ultraviolet-B irradiation induces differential regulations of hyaluronidase expression and activity in normal human keratinocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

Hyaluronidases and CD44 undergo differential modulation during chondrogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

Endocytosis of hyaluronidase-1 by the liver

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

Purification, cloning, and expression of human plasma hyaluronidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

Subtype specific elevated expression of hyaluronidase-1 (HYAL-1) in epithelial ovarian cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

HYAL1 overexpression is correlated with the malignant behavior of human breast cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

Designed human serum hyaluronidase 1 variant, HYAL1DeltaL, exhibits activity up to pH 5.9

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

determination method

1 reference

8 April 2019

Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

hyaluranon cable

determination method

1 reference

8 April 2019

Characterization of hyaluronan cable structure and function in renal proximal tubular epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

extracellular region

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

lysosomal lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

Expression and cellular localization of human hyaluronidase-2 in articular chondrocytes and cultured cell lines

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

Endocytosis of hyaluronidase-1 by the liver

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

extracellular exosome

determination method

cytoplasmic vesicle

determination method

1 reference

8 April 2019

Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

extracellular space

determination method

3 references

8 April 2019

Subtype specific elevated expression of hyaluronidase-1 (HYAL-1) in epithelial ovarian cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

Purification, cloning, and expression of human plasma hyaluronidase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

extracellular exosome

determination method

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

biological process

hyaluronan biosynthetic process

determination method

1 reference

8 April 2019

Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

hyaluronan catabolic process

determination method

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

Ultraviolet-B irradiation induces differential regulations of hyaluronidase expression and activity in normal human keratinocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

Subtype specific elevated expression of hyaluronidase-1 (HYAL-1) in epithelial ovarian cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

HYAL1 overexpression is correlated with the malignant behavior of human breast cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

8 April 2019

Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

positive regulation of hyaluranon cable assembly

determination method

1 reference

8 April 2019

Characterization of hyaluronan cable structure and function in renal proximal tubular epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

positive regulation of epithelial cell proliferation

determination method

1 reference

8 April 2019

Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

response to reactive oxygen species

determination method

1 reference

8 April 2019

Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

response to antibiotic

determination method

1 reference

8 April 2019

Hyaluronidases and CD44 undergo differential modulation during chondrogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

cellular response to tumor necrosis factor

determination method

1 reference

8 April 2019

Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

positive regulation of epithelial cell migration

determination method

1 reference

8 April 2019

Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

cellular response to platelet-derived growth factor stimulus

determination method

1 reference

8 April 2019

Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

positive regulation of growth

determination method

1 reference

8 April 2019

Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

cellular response to fibroblast growth factor stimulus

determination method

1 reference

8 April 2019

bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

positive regulation of angiogenesis

determination method

cellular response to pH

determination method

1 reference

8 April 2019

Designed human serum hyaluronidase 1 variant, HYAL1DeltaL, exhibits activity up to pH 5.9

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

cartilage development

determination method

1 reference

8 April 2019

Hyaluronidases and CD44 undergo differential modulation during chondrogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

positive regulation of cell growth

determination method

1 reference

8 April 2019

HYAL1 overexpression is correlated with the malignant behavior of human breast cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

cellular response to UV-B

determination method

1 reference

8 April 2019

Ultraviolet-B irradiation induces differential regulations of hyaluronidase expression and activity in normal human keratinocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

negative regulation of cell growth

determination method

1 reference

8 April 2019

HYAL1 and HYAL2 inhibit tumour growth in vivo but not in vitro

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

cellular response to interleukin-1

determination method

1 reference

8 April 2019

Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

chondroitin sulfate catabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

embryonic skeletal joint morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

inflammatory response

determination method

1 reference

8 April 2019

Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

positive regulation of cell adhesion

determination method

1 reference

8 April 2019

HYAL1 overexpression is correlated with the malignant behavior of human breast cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

hyaluronan metabolic process

determination method

1 reference

8 April 2019

Designed human serum hyaluronidase 1 variant, HYAL1DeltaL, exhibits activity up to pH 5.9

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

positive regulation of G1/S transition of mitotic cell cycle

determination method

1 reference

8 April 2019

Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

carbohydrate metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

response to virus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

viral entry into host cell

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000266031

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000266031

ENSP00000346068

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000346068

ENSP00000378575

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378575

ENSP00000378576

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378576

ENSP00000390149

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000390149

ENSP00000393358

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000393358

ENSP00000477903

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000477903

ENSP00000391666

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000391666

ENSP00000394526

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000394526

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21118410&oldid=2022973876"