Ribosomal protein S6 kinase A1 (Q21118360)

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mammalian protein found in Homo sapiens

MAPKAPK-1a
MAPKAP kinase 1a
ribosomal protein S6 kinase, 90kDa, polypeptide 1
ribosomal S6 kinase 1
MAPK-activated protein kinase 1a
ribosomal protein S6 kinase alpha-1
p90RSK1
S6K-alpha 1
RSK-1
90 kDa ribosomal protein S6 kinase 1
p90-RSK 1
dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)
p90S6K
MAP kinase-activated protein kinase 1a
RPS6KA1

Language	Label	Description	Also known as
English	Ribosomal protein S6 kinase A1	mammalian protein found in Homo sapiens	MAPKAPK-1a MAPKAP kinase 1a ribosomal protein S6 kinase, 90kDa, polypeptide 1 ribosomal S6 kinase 1 MAPK-activated protein kinase 1a ribosomal protein S6 kinase alpha-1 p90RSK1 S6K-alpha 1 RSK-1 90 kDa ribosomal protein S6 kinase 1 p90-RSK 1 dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1) p90S6K MAP kinase-activated protein kinase 1a RPS6KA1

Statements

1 reference

13 November 2019

UniProt protein ID

ribosomal protein S6 kinase II

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15418

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15418

Protein kinase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

AGC-kinase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

protein kinase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

determination method

1 reference

8 April 2019

Anti-apoptotic actions of vasopressin in H32 neurons involve MAP kinase transactivation and Bad phosphorylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

protein serine/threonine kinase activity

determination method

5 references

8 April 2019

Human rsk isoforms: cloning and characterization of tissue-specific expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

8 April 2019

Rsk1 mediates a MEK-MAP kinase cell survival signal

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

8 April 2019

P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

protein binding

determination method

7 references

8 April 2019

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

8 April 2019

Proteome-wide analysis of phospho-regulated PDZ domain interactions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

8 April 2019

An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

8 April 2019

RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

8 April 2019

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

8 April 2019

Localization and retention of p90 ribosomal S6 kinase 1 in the nucleus: implications for its function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

8 April 2019

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

protein serine/threonine/tyrosine kinase activity

determination method

1 reference

8 April 2019

ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

determination method

2 references

magnesium ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

ribosomal protein S6 kinase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

biological process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

determination method

1 reference

8 April 2019

Anti-apoptotic actions of vasopressin in H32 neurons involve MAP kinase transactivation and Bad phosphorylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

regulation of translation in response to stress

determination method

1 reference

8 April 2019

The RSK family of kinases: emerging roles in cellular signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

negative regulation of apoptotic process

determination method

1 reference

8 April 2019

C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

protein phosphorylation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

positive regulation of cell growth

determination method

1 reference

8 April 2019

The RSK family of kinases: emerging roles in cellular signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

hepatocyte proliferation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

positive regulation of cell differentiation

determination method

1 reference

8 April 2019

The RSK family of kinases: emerging roles in cellular signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

positive regulation of hepatic stellate cell activation

determination method

1 reference

8 April 2019

Rsk1 mediates a MEK-MAP kinase cell survival signal

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

regulation of DNA-templated transcription in response to stress

determination method

1 reference

8 April 2019

The RSK family of kinases: emerging roles in cellular signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

signal transduction

determination method

1 reference

8 April 2019

Human rsk isoforms: cloning and characterization of tissue-specific expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

apoptotic process

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

intracellular signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15418

determination method

AGC-kinase, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15418

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15418

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15418

protein kinase, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15418

serine/threonine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15418

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000363283

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000363283

ENSP00000431651

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000431651

ENSP00000432281

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000432281

ENSP00000435412

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000435412

ENSP00000486881

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486881

ENSP00000487166

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000487166

ENSP00000487349

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000487349

ENSP00000487553

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000487553

ENSP00000486031

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486031

ENSP00000486849

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486849

ENSP00000487154

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000487154

ENSP00000434616

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000434616

ENSP00000486119

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486119

ENSP00000355831

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000355831

ENSP00000485797

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000485797

ENSP00000436990

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000436990

ENSP00000363281

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000363281

ENSP00000433039

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000433039

ENSP00000487207

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000487207

ENSP00000487239

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000487239

ENSP00000383967

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000383967

ENSP00000363278

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000363278

ENSP00000403548

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000403548

ENSP00000486179

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486179

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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