Four and a half LIM domains 2 (Q21116824)

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mammalian protein found in Homo sapiens

four and a half LIM domains protein 2
down-regulated in rhabdomyosarcoma LIM protein
LIM domain protein DRAL
skeletal muscle LIM-protein 3
aging-associated gene 11
FHL2
SLIM-3

Language	Label	Description	Also known as
English	Four and a half LIM domains 2	mammalian protein found in Homo sapiens	four and a half LIM domains protein 2 down-regulated in rhabdomyosarcoma LIM protein LIM domain protein DRAL skeletal muscle LIM-protein 3 aging-associated gene 11 FHL2 SLIM-3

Statements

1 reference

13 November 2019

UniProt protein ID

Four and a half LIM domains protein 2/3/5

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14192

Zinc finger, LIM-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transcription coactivator activity

determination method

1 reference

8 April 2019

Negative modulation of androgen receptor transcriptional activity by Daxx

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

transcription factor binding

determination method

1 reference

8 April 2019

Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

protein binding

determination method

13 references

8 April 2019

The novel cardiac z-disc protein CEFIP regulates cardiomyocyte hypertrophy by modulating calcineurin signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

8 April 2019

Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

8 April 2019

Site-specific proteolysis of the transcriptional coactivator HCF-1 can regulate its interaction with protein cofactors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

8 April 2019

Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

8 April 2019

FHL2 interacts with CALM and is highly expressed in acute erythroid leukemia.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

8 April 2019

Next-generation sequencing to generate interactome datasets

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

8 April 2019

FHL2/SLIM3 decreases cardiomyocyte survival by inhibitory interaction with sphingosine kinase-1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

8 April 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

8 April 2019

A protein-protein interaction network of transcription factors acting during liver cell proliferation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

8 April 2019

BRCA1 interacts with FHL2 and enhances FHL2 transactivation function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

8 April 2019

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

8 April 2019

ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

androgen receptor binding

determination method

1 reference

8 April 2019

Negative modulation of androgen receptor transcriptional activity by Daxx

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

identical protein binding

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

determination method

1 reference

17 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14192&geneProductId=UniProtKB:Q14192

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

determination method

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14192&geneProductId=UniProtKB:Q14192

determination method

determination method

3 references

17 October 2017

Subtractive cloning and characterization of DRAL, a novel LIM-domain protein down-regulated in rhabdomyosarcoma

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14192&geneProductId=UniProtKB:Q14192

determination method

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14192&geneProductId=UniProtKB:Q14192

determination method

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14192&geneProductId=UniProtKB:Q14192

determination method

determination method

3 references

8 April 2019

Subtractive cloning and characterization of DRAL, a novel LIM-domain protein down-regulated in rhabdomyosarcoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

determination method

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

biological process

androgen receptor signaling pathway

determination method

1 reference

8 April 2019

Negative modulation of androgen receptor transcriptional activity by Daxx

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

regulation of transcription, DNA-templated

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14192&geneProductId=UniProtKB:Q14192

determination method

heart trabecula formation

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

negative regulation of apoptotic process

determination method

1 reference

8 April 2019

Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

transcription, DNA-templated

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14192&geneProductId=UniProtKB:Q14192

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Negative modulation of androgen receptor transcriptional activity by Daxx

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

osteoblast differentiation

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

response to hormone

determination method

1 reference

8 April 2019

Androgen induction of the androgen receptor coactivator four and a half LIM domain protein-2: evidence for a role for serum response factor in prostate cancer

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

atrial cardiac muscle cell development

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

ventricular cardiac muscle cell development

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

regulation of lipid metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

negative regulation of calcineurin-NFAT signaling cascade

determination method

1 reference

8 April 2019

FHL2 binds calcineurin and represses pathological cardiac growth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14192

determination method

Zinc finger, LIM-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14192

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000322909

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000322909

ENSP00000350846

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000350846

ENSP00000377020

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000377020

ENSP00000377021

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000377021

ENSP00000386633

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000386633

ENSP00000386665

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000386665

ENSP00000344266

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000344266

ENSP00000386892

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000386892

ENSP00000397083

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000397083

ENSP00000414872

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000414872

ENSP00000433567

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000433567

ENSP00000476199

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000476199

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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