ATPase plasma membrane Ca2+ transporting 2 (Q21115347)

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mammalian protein found in Homo sapiens

ATPase, Ca++ transporting, plasma membrane 2
ATP2B2
plasma membrane Ca(2+)-ATPase
plasma membrane calcium-transporting ATPase 2
Plasma membrane calcium pump isoform 2
plasma membrane calcium pump
plasma membrane calcium ATPase
plasma membrane Ca2+ pump 2
Plasma membrane calcium ATPase isoform 2

Language	Label	Description	Also known as
English	ATPase plasma membrane Ca2+ transporting 2	mammalian protein found in Homo sapiens	ATPase, Ca++ transporting, plasma membrane 2 ATP2B2 plasma membrane Ca(2+)-ATPase plasma membrane calcium-transporting ATPase 2 Plasma membrane calcium pump isoform 2 plasma membrane calcium pump plasma membrane calcium ATPase plasma membrane Ca2+ pump 2 Plasma membrane calcium ATPase isoform 2

Statements

1 reference

13 November 2019

UniProt protein ID

P-type ATPase, A domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01814

HAD-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01814

Plasma membrane calcium-transporting ATPase 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01814

P-type ATPase, transmembrane domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01814

P-type ATPase, cytoplasmic domain N

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01814

HAD superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01814

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Cation-transporting P-type ATPase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Plasma membrane calcium transporting P-type ATPase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cation-transporting P-type ATPase, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

calcium ion binding

determination method

1 reference

26 September 2017

Cloning and expression of isoform 2 of the human plasma membrane Ca2+ ATPase. Functional properties of the enzyme and its splicing products

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

protein C-terminus binding

determination method

1 reference

26 September 2017

Plasma membrane Ca2+ ATPase isoform 2b interacts preferentially with Na+/H+ exchanger regulatory factor 2 in apical plasma membranes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

protein binding

determination method

3 references

8 April 2019

Proteome-wide analysis of phospho-regulated PDZ domain interactions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

8 April 2019

The interaction between endogenous calcineurin and the plasma membrane calcium-dependent ATPase is isoform specific in breast cancer cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

8 April 2019

Plasma membrane Ca2+ ATPase isoform 2b interacts preferentially with Na+/H+ exchanger regulatory factor 2 in apical plasma membranes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

determination method

3 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

26 September 2017

Cloning and expression of isoform 2 of the human plasma membrane Ca2+ ATPase. Functional properties of the enzyme and its splicing products

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

hydrolase activity

determination method

1 reference

14 January 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

P-type calcium transporter activity

determination method

6 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

26 September 2017

Microdiversity of human‐plasma‐membrane calcium‐pump isoform 2 generated by alternative RNA splicing in the N‐terminal coding region

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

26 September 2017

Cloning and expression of isoform 2 of the human plasma membrane Ca2+ ATPase. Functional properties of the enzyme and its splicing products

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

P-type calcium transporter activity

determination method

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

1 January 2018

Microdiversity of human‐plasma‐membrane calcium‐pump isoform 2 generated by alternative RNA splicing in the N‐terminal coding region

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

calmodulin binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

determination method

2 references

PDZ domain binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration

determination method

1 reference

8 April 2019

Cloning and expression of isoform 2 of the human plasma membrane Ca2+ ATPase. Functional properties of the enzyme and its splicing products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration

determination method

P-type calcium transporter activity

determination method

3 references

8 April 2019

Microdiversity of human‐plasma‐membrane calcium‐pump isoform 2 generated by alternative RNA splicing in the N‐terminal coding region

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

determination method

1 reference

8 April 2019

Expression and immunolocalization of plasma membrane calcium ATPase isoforms in human corneal epithelium

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

intracellular membrane-bounded organelle

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

determination method

2 references

plasma membrane

determination method

6 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

26 September 2017

Microdiversity of human‐plasma‐membrane calcium‐pump isoform 2 generated by alternative RNA splicing in the N‐terminal coding region

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

26 September 2017

Alternative splicing of the first intracellular loop of plasma membrane Ca2+-ATPase isoform 2 alters its membrane targeting

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

26 September 2017

Cloning and expression of isoform 2 of the human plasma membrane Ca2+ ATPase. Functional properties of the enzyme and its splicing products

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

26 September 2017

Plasma membrane Ca2+ ATPase isoform 2b interacts preferentially with Na+/H+ exchanger regulatory factor 2 in apical plasma membranes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

integral component of plasma membrane

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

extracellular exosome

determination method

1 reference

26 September 2017

Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

plasma membrane

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

8 April 2019

Microdiversity of human‐plasma‐membrane calcium‐pump isoform 2 generated by alternative RNA splicing in the N‐terminal coding region

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

extracellular exosome

determination method

1 reference

8 April 2019

Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

postsynaptic density membrane

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

glutamatergic synapse

determination method

GABA-ergic synapse

determination method

biological process

regulation of cardiac conduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

ion transmembrane transport

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

neuron differentiation

determination method

1 reference

8 April 2019

Differentiation induces up-regulation of plasma membrane Ca(2+)-ATPase and concomitant increase in Ca(2+) efflux in human neuroblastoma cell line IMR-32

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

calcium ion transmembrane transport

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

regulation of cytosolic calcium ion concentration

determination method

1 reference

26 September 2017

A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01814&geneProductId=UniProtKB:Q01814

determination method

calcium ion transport

determination method

3 references

8 April 2019

Microdiversity of human‐plasma‐membrane calcium‐pump isoform 2 generated by alternative RNA splicing in the N‐terminal coding region

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

8 April 2019

A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

cellular calcium ion homeostasis

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

regulation of presynaptic cytosolic calcium ion concentration

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

regulation of postsynaptic cytosolic calcium ion concentration

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01814

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000324172

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000324172

ENSP00000353414

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000353414

ENSP00000380267

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000380267

ENSP00000424494

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000424494

ENSP00000414854

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000414854

ENSP00000492732

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000492732

ENSP00000494381

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494381

ENSP00000495924

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495924

ENSP00000494004

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494004

ENSP00000495228

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495228

ENSP00000494716

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494716

ENSP00000494252

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494252

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

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