HCK proto-oncogene, Src family tyrosine kinase (Q21113798)

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mammalian protein found in Homo sapiens
  • p59Hck
  • hemopoietic cell kinase
  • p61Hck
  • hematopoietic cell kinase
  • HCK
  • tyrosine-protein kinase HCK
  • p59-HCK/p60-HCK
  • Proto-Oncogene Proteins c-hck
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Language Label Description Also known as
English
HCK proto-oncogene, Src family tyrosine kinase
mammalian protein found in Homo sapiens
  • p59Hck
  • hemopoietic cell kinase
  • p61Hck
  • hematopoietic cell kinase
  • HCK
  • tyrosine-protein kinase HCK
  • p59-HCK/p60-HCK
  • Proto-Oncogene Proteins c-hck

Statements

molecular function
protein binding
determination method
IPI
21 references
retrieved
8 April 2019
stated in
Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4
GOA
curator
UniProt
UniProt protein ID
P08631
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
retrieved
8 April 2019
stated in
Molecular characterization of WDCP, a novel fusion partner for the anaplastic lymphoma tyrosine kinase ALK
GOA
curator
UniProt
UniProt protein ID
P08631
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
retrieved
8 April 2019
stated in
Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1
GOA
curator
UniProt
UniProt protein ID
P08631
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
retrieved
8 April 2019
stated in
Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
retrieved
8 April 2019
stated in
Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
retrieved
8 April 2019
stated in
A quantitative protein interaction network for the ErbB receptors using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
retrieved
8 April 2019
stated in
Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
retrieved
8 April 2019
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
retrieved
8 April 2019
stated in
Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of 5-lipoxygenase phosphorylation on molecular level by MALDI-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
retrieved
8 April 2019
stated in
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
retrieved
8 April 2019
stated in
Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
retrieved
8 April 2019
stated in
Solution structure of a Hck SH3 domain ligand complex reveals novel interaction modes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
retrieved
8 April 2019
stated in
Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
retrieved
8 April 2019
stated in
The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
retrieved
8 April 2019
stated in
The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
retrieved
8 April 2019
stated in
Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
retrieved
8 April 2019
stated in
Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
determination method
IPI
protein tyrosine kinase activity
determination method
IEA
IMP
EXP
TAS
6 references
retrieved
7 November 2018
stated in
Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P08631&geneProductId=UniProtKB:P08631
determination method
TAS
retrieved
7 November 2018
stated in
The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase
GOA
curator
UniProt
UniProt protein ID
P08631
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P08631&geneProductId=UniProtKB:P08631
determination method
IMP
retrieved
7 November 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P08631
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P08631&geneProductId=UniProtKB:P08631
determination method
IEA
retrieved
7 November 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P08631&geneProductId=UniProtKB:P08631
determination method
IEA
retrieved
7 November 2018
stated in
Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P08631&geneProductId=UniProtKB:P08631
determination method
EXP
retrieved
7 November 2018
stated in
Differential involvement of Src family kinases in Fc gamma receptor-mediated phagocytosis
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P08631&geneProductId=UniProtKB:P08631
determination method
EXP
cell component
biological process

Identifiers

MeSH descriptor ID
D051572
subject named as
Proto-Oncogene Proteins c-hck
0 references
PDB structure ID
 
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