SLX4 structure-specific endonuclease subunit (Q21113251)

http://www.ebi.ac.uk/interpro/protein/Q8IY92

Structure-specific endonuclease subunit Slx4

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IY92

BTB/POZ domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

8 references

8 April 2019

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

enzyme activator activity

IPI

1 reference

8 April 2019

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

endodeoxyribonuclease activity

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IY92&geneProductId=UniProtKB:Q8IY92

crossover junction endodeoxyribonuclease activity

TAS

3 references

27 March 2018

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IY92&geneProductId=UniProtKB:Q8IY92

27 March 2018

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IY92&geneProductId=UniProtKB:Q8IY92

27 March 2018

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IY92&geneProductId=UniProtKB:Q8IY92

5'-flap endonuclease activity

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IY92&geneProductId=UniProtKB:Q8IY92

27 March 2018

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IY92&geneProductId=UniProtKB:Q8IY92

27 March 2018

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IY92&geneProductId=UniProtKB:Q8IY92

27 March 2018

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IY92&geneProductId=UniProtKB:Q8IY92

3'-flap endonuclease activity

crossover junction endodeoxyribonuclease activity

4 references

8 April 2019

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

5'-flap endonuclease activity

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

3'-flap endonuclease activity

3 references

8 April 2019

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

3 references

8 April 2019

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

Holliday junction resolvase complex

3 references

8 April 2019

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

2 references

1 reference

8 April 2019

SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

5 references

27 March 2018

SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IY92&geneProductId=UniProtKB:Q8IY92

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IY92&geneProductId=UniProtKB:Q8IY92

27 March 2018

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IY92&geneProductId=UniProtKB:Q8IY92

27 March 2018

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IY92&geneProductId=UniProtKB:Q8IY92

27 March 2018

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IY92&geneProductId=UniProtKB:Q8IY92

6 references

8 April 2019

SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

nucleotide-excision repair

biological process

1 reference

8 April 2019

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

cellular response to DNA damage stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

DNA double-strand break processing involved in repair via single-strand annealing

1 reference

8 April 2019

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

response to intra-S DNA damage checkpoint signaling

1 reference

8 April 2019

FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

positive regulation of catalytic activity

IMP

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

3 references

8 April 2019

Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

resolution of meiotic recombination intermediates

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

double-strand break repair via homologous recombination

meiotic DNA double-strand break processing

IMP

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

telomeric D-loop disassembly

1 reference

8 April 2019

SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

3 references

negative regulation of telomere maintenance via telomere lengthening

1 reference

8 April 2019

SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IY92

1 reference

InterPro Release 71.0