Poly(A) binding protein cytoplasmic 1 (Q21112715)

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mammalian protein found in Homo sapiens
  • polyadenylate-binding protein 1
  • poly(A) binding protein, cytoplasmic 2
  • PABPC1
edit
Language Label Description Also known as
English
Poly(A) binding protein cytoplasmic 1
mammalian protein found in Homo sapiens
  • polyadenylate-binding protein 1
  • poly(A) binding protein, cytoplasmic 2
  • PABPC1

Statements

molecular function
protein binding
determination method
IPI
49 references
retrieved
8 April 2019
stated in
Poly(A)-binding protein and eRF3 are associated in vivo in human and Xenopus cells
GOA
curator
UniProt
UniProt protein ID
P11940
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation
GOA
curator
UniProt
UniProt protein ID
P11940
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85
GOA
curator
UniProt
UniProt protein ID
P11940
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
La-Related Protein 4 Binds Poly(A), Interacts with the Poly(A)-Binding Protein MLLE Domain via a Variant PAM2w Motif, and Can Promote mRNA Stability
GOA
curator
UniProt
UniProt protein ID
P11940
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Paip1 interacts with poly(A) binding protein through two independent binding motifs
GOA
curator
UniProt
UniProt protein ID
P11940
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA
GOA
curator
UniProt
UniProt protein ID
P11940
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Molecular composition of IMP1 ribonucleoprotein granules
GOA
curator
UniProt
UniProt protein ID
P11940
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Translational repression by a novel partner of human poly(A) binding protein, Paip2
GOA
curator
UniProt
UniProt protein ID
P11940
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma
GOA
curator
UniProt
UniProt protein ID
P11940
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation
GOA
curator
UniProt
UniProt protein ID
P11940
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication
GOA
curator
UniProt
UniProt protein ID
P11940
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration
GOA
curator
UniProt
UniProt protein ID
P11940
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts
GOA
curator
UniProt
UniProt protein ID
P11940
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment
GOA
curator
UniProt
UniProt protein ID
P11940
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function
GOA
curator
UniProt
UniProt protein ID
P11940
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells
GOA
curator
UniProt
UniProt protein ID
P11940
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Both G3BP1 and G3BP2 contribute to stress granule formation
GOA
curator
UniProt
UniProt protein ID
P11940
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Proteomics of herpes simplex virus infected cell protein 27: association with translation initiation factors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Cadherin complexes recruit mRNAs and RISC to regulate epithelial cell signaling.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Assembly of AUF1 with eIF4G-poly(A) binding protein complex suggests a translation function in AU-rich mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Recognition of eIF4G by rotavirus NSP3 reveals a basis for mRNA circularization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
An integrative approach to gain insights into the cellular function of human ataxin-2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation at intrinsically disordered regions of PAM2 motif-containing proteins modulates their interactions with PABPC1 and influences mRNA fate
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Paip1 interacts with poly(A) binding protein through two independent binding motifs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative characterization of Tob interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Molecular basis of eRF3 recognition by the MLLE domain of poly(A)-binding protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
retrieved
8 April 2019
stated in
Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IPI
RNA binding
determination method
HDA
IBA
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P11940
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IEA
retrieved
8 April 2019
stated in
Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
IBA
retrieved
8 April 2019
stated in
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts
GOA
curator
UniProt
UniProt protein ID
P11940
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
HDA
retrieved
8 April 2019
stated in
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins
GOA
curator
UniProt
UniProt protein ID
P11940
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11940
determination method
HDA
cell component
biological process

Identifiers

Ensembl protein ID
PDB structure ID
 
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