autocrine motility factor receptor (Q21112658)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UKV5

Zinc finger, RING-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin system component Cue, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

protein-macromolecule adaptor activity

1 reference

9 May 2019

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

2 references

ubiquitin protein ligase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

ubiquitin-protein transferase activity

5 references

9 May 2019

Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

ubiquitin-ubiquitin ligase activity

1 reference

9 May 2019

Polyubiquitylation of AMF requires cooperation between the gp78 and TRIM25 ubiquitin ligases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

12 references

9 May 2019

Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

RING finger palmitoylation of the endoplasmic reticulum Gp78 E3 ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

Polyubiquitylation of AMF requires cooperation between the gp78 and TRIM25 ubiquitin ligases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

Characterization of an Additional Binding Surface on the p97 N-Terminal Domain Involved in Bipartite Cofactor Interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

Mechanistic insights into active site-associated polyubiquitination by the ubiquitin-conjugating enzyme Ube2g2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

ubiquitin-specific protease binding

IPI

1 reference

9 May 2019

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

identical protein binding

3 references

9 May 2019

Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

Mechanistic insights into active site-associated polyubiquitination by the ubiquitin-conjugating enzyme Ube2g2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

signaling receptor activity

1 reference

9 May 2019

Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

ubiquitin protein ligase activity

IPI

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

8 April 2019

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

8 April 2019

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

8 April 2019

A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

ubiquitin protein ligase activity

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

integral component of endoplasmic reticulum membrane

1 reference

9 May 2019

The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

Derlin-1 retrotranslocation complex

1 reference

9 May 2019

Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

perinuclear region of cytoplasm

1 reference

9 May 2019

Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

endoplasmic reticulum

3 references

8 April 2019

8 April 2019

RING finger palmitoylation of the endoplasmic reticulum Gp78 E3 ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

endoplasmic reticulum membrane

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

endoplasmic reticulum quality control compartment

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

protein-containing complex

1 reference

9 May 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

ubiquitin ligase complex

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

IBA

endoplasmic reticulum

4 references

9 May 2019

9 May 2019

RING finger palmitoylation of the endoplasmic reticulum Gp78 E3 ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

1 reference

31 October 2017

Polyubiquitylation of AMF requires cooperation between the gp78 and TRIM25 ubiquitin ligases

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKV5&geneProductId=UniProtKB:Q9UKV5

ubiquitin-dependent protein catabolic process

IC

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

protein polyubiquitination

3 references

9 May 2019

Polyubiquitylation of AMF requires cooperation between the gp78 and TRIM25 ubiquitin ligases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

endoplasmic reticulum unfolded protein response

1 reference

8 April 2019

ER stress differentially regulates the stabilities of ERAD ubiquitin ligases and their substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

protein K48-linked ubiquitination

IMP

2 references

8 April 2019

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

8 April 2019

Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

protein complex oligomerization

1 reference

9 May 2019

A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

protein ubiquitination

1 reference

8 April 2019

ubiquitin-dependent ERAD pathway

4 references

31 October 2017

Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKV5&geneProductId=UniProtKB:Q9UKV5

31 October 2017

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKV5&geneProductId=UniProtKB:Q9UKV5

31 October 2017

Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKV5&geneProductId=UniProtKB:Q9UKV5

31 October 2017

The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKV5&geneProductId=UniProtKB:Q9UKV5

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

positive regulation of protein binding

1 reference

9 May 2019

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

1 reference

9 May 2019

Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

protein autoubiquitination

TAS

1 reference

9 May 2019

Polyubiquitylation of AMF requires cooperation between the gp78 and TRIM25 ubiquitin ligases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

endoplasmic reticulum mannose trimming

TAS

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

ubiquitin-dependent ERAD pathway

TAS

5 references

9 May 2019

Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

Polyubiquitylation of AMF requires cooperation between the gp78 and TRIM25 ubiquitin ligases

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

ubiquitin-dependent protein catabolic process

IC

3 references

9 May 2019

Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

protein K48-linked ubiquitination

IBA

3 references

9 May 2019

Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5

IBA

has part(s)

Zinc finger, RING-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UKV5

Ubiquitin system component Cue

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UKV5

Identifiers

MeSH descriptor ID

D060285

subject named as

Receptors, Autocrine Motility Factor

0 references

MeSH tree code

D08.811.464.938.750.656

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference