Nuclear receptor subfamily 1 group H member 3 (Q21112289)

Zinc finger, NHR/GATA-type

1 reference

liver X receptor

1 reference

Nuclear hormone receptor, ligand-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, nuclear hormone receptor-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

Role of LXRs in control of lipogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

11 references

8 April 2019

GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

Next-generation sequencing to generate interactome datasets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

Molecular determinants of the interactions between SRC-1 and LXR/RXR heterodimers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

Tumor suppressor Menin acts as a corepressor of LXRα to inhibit hepatic lipogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

A Y2H-seq approach defines the human protein methyltransferase interactome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

nuclear receptor activity

1 reference

8 April 2019

LXR, a nuclear receptor that defines a distinct retinoid response pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

sterol response element binding

1 reference

8 April 2019

Induction of transglutaminase 2 by a liver X receptor/retinoic acid receptor alpha pathway increases the clearance of apoptotic cells by human macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

steroid hormone receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

sequence-specific DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

DNA-binding transcription factor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

DNA-binding transcription factor activity, RNA polymerase II-specific

3 references

24 April 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

24 April 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

24 April 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

transcription cis-regulatory region binding

ISA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

DNA-binding transcription factor activity, RNA polymerase II-specific

4 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

transcription factor binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

nuclear receptor coactivator activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

signaling receptor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

1 reference

8 April 2019

The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

RNA polymerase II transcription regulator complex

1 reference

24 April 2018

The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

4 references

24 April 2018

LXR, a nuclear receptor that defines a distinct retinoid response pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

24 April 2018

CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

5 references

8 April 2019

LXR, a nuclear receptor that defines a distinct retinoid response pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

2 references

RNA polymerase II transcription regulator complex

positive regulation of toll-like receptor 4 signaling pathway

1 reference

8 April 2019

The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

negative regulation of pancreatic juice secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

negative regulation of inflammatory response

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

cellular response to lipopolysaccharide

1 reference

24 April 2018

The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

negative regulation of lipid transport

1 reference

8 April 2019

Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

positive regulation of lipoprotein lipase activity

1 reference

8 April 2019

Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

triglyceride homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

negative regulation of macrophage activation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

negative regulation of macrophage derived foam cell differentiation

1 reference

8 April 2019

Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

positive regulation of cholesterol transport

IC

1 reference

8 April 2019

Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

negative regulation of cholesterol storage

1 reference

8 April 2019

Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

regulation of transcription, DNA-templated

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

positive regulation of triglyceride biosynthetic process

1 reference

8 April 2019

Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

positive regulation of cholesterol efflux

3 references

8 April 2019

Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

positive regulation of protein metabolic process

1 reference

8 April 2019

Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

negative regulation of interferon-gamma-mediated signaling pathway

1 reference

8 April 2019

Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

regulation of circadian rhythm

NAS

1 reference

8 April 2019

The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

negative regulation of transcription by RNA polymerase II

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages

response to progesterone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

steroid hormone mediated signaling pathway

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

Induction of transglutaminase 2 by a liver X receptor/retinoic acid receptor alpha pathway increases the clearance of apoptotic cells by human macrophages

apoptotic cell clearance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

positive regulation of fatty acid biosynthetic process

1 reference

8 April 2019

Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

transcription initiation from RNA polymerase II promoter

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

positive regulation of transcription by RNA polymerase II

7 references

24 April 2018

Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

24 April 2018

FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

24 April 2018

GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

24 April 2018

Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

24 April 2018

The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

24 April 2018

Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

24 April 2018

Regulation of LPCAT3 by LXR

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

negative regulation of secretion of lysosomal enzymes

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

negative regulation of pinocytosis

1 reference

8 April 2019

Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

positive regulation of transcription, DNA-templated

intracellular receptor signaling pathway

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

cholesterol homeostasis

3 references

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

24 April 2018

The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13133&geneProductId=UniProtKB:Q13133

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

multicellular organism development

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

cholesterol homeostasis

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

positive regulation of transcription by RNA polymerase II

8 references

8 April 2019

Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

Regulation of LPCAT3 by LXR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

cellular response to lipopolysaccharide

negative regulation of cold-induced thermogenesis

1 reference

8 April 2019

Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13133

physically interacts with

(25R)-cholest-5-ene-3β,26-diol

has use

agonist

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2752

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

2748

nuclear hormone receptor-type zinc finger

English

retrieved

17 August 2016

has part(s)

1 reference

Nuclear hormone receptor, ligand-binding domain

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

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30 May 2020

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30 May 2020

1 reference

30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

1 reference

13 November 2019

1 reference

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9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016