receptor interacting serine/threonine kinase 2 (Q21111679)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O43353

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O43353

Death-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O43353

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

CARD domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

TRIP6 is a RIP2-associated common signaling component of multiple NF-kappaB activation pathways

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

signaling receptor binding

1 reference

8 April 2019

The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

2 references

protein kinase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

non-membrane spanning protein tyrosine kinase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

protein homodimerization activity

1 reference

8 April 2019

Evaluation of Nod-like receptor (NLR) effector domain interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

17 references

8 April 2019

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

XIAP mediates NOD signaling via interaction with RIP2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

Identification and characterization of receptor-interacting protein 2 as a TNFR-associated factor 3 binding partner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

Evaluation of Nod-like receptor (NLR) effector domain interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

signal transducer activity

1 reference

24 April 2018

RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43353&geneProductId=UniProtKB:O43353

protein serine/threonine kinase activity

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

identical protein binding

1 reference

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

3 references

8 April 2019

INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

JUN kinase kinase kinase activity

IPI

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

1 reference

8 April 2019

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

1 reference

8 April 2019

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

protein-containing complex

4 references

8 April 2019

Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

response to interleukin-1

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of cytokine-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

response to exogenous dsRNA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of JNK cascade

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of xenophagy

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

cellular response to muramyl dipeptide

1 reference

8 April 2019

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

protein phosphorylation

1 reference

8 April 2019

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

cellular response to peptidoglycan

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of stress-activated MAPK cascade

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

defense response to Gram-positive bacterium

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of immature T cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of interleukin-12 production

1 reference

8 April 2019

Activation of interferon regulatory factor 5 by site specific phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of interferon-alpha production

NAS

1 reference

8 April 2019

Activation of interferon regulatory factor 5 by site specific phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of peptidyl-serine phosphorylation

NAS

1 reference

8 April 2019

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

response to interleukin-12

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of T-helper 1 type immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of alpha-beta T cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of interleukin-6 production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of tumor necrosis factor production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

Identification of CARDIAK, a RIP-like kinase that associates with caspase-1

inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

nucleotide-binding oligomerization domain containing 1 signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of interferon-beta production

1 reference

8 April 2019

Activation of interferon regulatory factor 5 by site specific phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

immune system process

1 reference

8 April 2019

positive regulation of T-helper 1 cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

negative regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

cellular response to lipoteichoic acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of interleukin-2 production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of chemokine production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

nucleotide-binding oligomerization domain containing signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

lipopolysaccharide-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of interferon-gamma production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of peptidyl-threonine phosphorylation

1 reference

8 April 2019

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

cellular response to lipopolysaccharide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

T cell receptor signaling pathway

response to interleukin-18

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

1 reference

8 April 2019

RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Activation of interferon regulatory factor 5 by site specific phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

toll-like receptor 4 signaling pathway

NAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

toll-like receptor 2 signaling pathway

1 reference

8 April 2019

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43353&geneProductId=UniProtKB:O43353

innate immune response

4 references

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43353&geneProductId=UniProtKB:O43353

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43353&geneProductId=UniProtKB:O43353

16 July 2018

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43353&geneProductId=UniProtKB:O43353

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

adaptive immune response

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of protein binding

1 reference

8 April 2019

Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of NF-kappaB transcription factor activity

IMP

5 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43353&geneProductId=UniProtKB:O43353

16 July 2018

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43353&geneProductId=UniProtKB:O43353

16 July 2018

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43353&geneProductId=UniProtKB:O43353

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43353&geneProductId=UniProtKB:O43353

16 July 2018

CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43353&geneProductId=UniProtKB:O43353

activation of cysteine-type endopeptidase activity

1 reference

8 April 2019

CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of cell death

1 reference

8 April 2019

Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

interleukin-1-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

innate immune response

5 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

positive regulation of NF-kappaB transcription factor activity

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353

http://www.uniprot.org/uniprot/O43353.txt?version=170

EC enzyme number

2.7.10.2

1 reference

14 November 2015

Identifiers

MeSH descriptor ID

D053475

subject named as

Receptor-Interacting Protein Serine-Threonine Kinase 2

0 references

MeSH tree code

D08.811.913.696.620.682.700.801.500

0 references

D12.776.157.057.006.750

0 references

D12.776.157.057.500.186.500

0 references

D12.776.476.024.139.750

0 references

D12.776.476.024.500.186.500

0 references

D12.776.476.075.358.750

0 references

D12.776.476.563.801.500

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference