Egl-9 family hypoxia inducible factor 1 (Q21110136)

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mammalian protein found in Homo sapiens

HPH-2
egl nine-like protein 1
hypoxia-inducible factor prolyl hydroxylase 2
zinc finger MYND domain-containing protein 6
HIF-PH2
prolyl hydroxylase domain-containing protein 2
SM-20
EGLN1
egl nine homolog 1
HIF-prolyl hydroxylase 2
PHD2

Language	Label	Description	Also known as
English	Egl-9 family hypoxia inducible factor 1	mammalian protein found in Homo sapiens	HPH-2 egl nine-like protein 1 hypoxia-inducible factor prolyl hydroxylase 2 zinc finger MYND domain-containing protein 6 HIF-PH2 prolyl hydroxylase domain-containing protein 2 SM-20 EGLN1 egl nine homolog 1 HIF-prolyl hydroxylase 2 PHD2

Statements

1 reference

16 January 2019

UniProt protein ID

Zinc finger, MYND-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Prolyl 4-hydroxylase, alpha subunit, protein family

1 reference

based on heuristic

inferred from protein domain or family

Oxoglutarate/iron-dependent dioxygenase family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

16 January 2019

UniProt protein ID

1 reference

16 January 2019

UniProt protein ID

molecular function

2-oxoglutarate-dependent dioxygenase activity

determination method

1 reference

8 April 2019

Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

iron ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

dioxygenase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

protein binding

determination method

9 references

8 April 2019

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

8 April 2019

SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

8 April 2019

Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

8 April 2019

Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

8 April 2019

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

8 April 2019

OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

8 April 2019

The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

8 April 2019

Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

8 April 2019

Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

peptidyl-proline dioxygenase activity

determination method

1 reference

8 April 2019

IOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1alpha activity

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

peptidyl-proline 4-dioxygenase activity

determination method

4 references

8 April 2019

A conserved family of prolyl-4-hydroxylases that modify HIF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

8 April 2019

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

8 April 2019

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

8 April 2019

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

ferrous iron binding

determination method

1 reference

8 April 2019

1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

determination method

postsynaptic density

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

glutamatergic synapse

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

biological process

response to hypoxia

determination method

1 reference

8 April 2019

IOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1alpha activity

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

heart trabecula formation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

ventricular septum morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

labyrinthine layer development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

response to nitric oxide

determination method

1 reference

8 April 2019

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

determination method

1 reference

8 April 2019

A conserved family of prolyl-4-hydroxylases that modify HIF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

cardiac muscle tissue morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

negative regulation of DNA-binding transcription factor activity

determination method

1 reference

8 April 2019

IOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1alpha activity

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

regulation of transcription from RNA polymerase II promoter in response to hypoxia

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

negative regulation of cyclic-nucleotide phosphodiesterase activity

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

oxygen homeostasis

determination method

1 reference

8 April 2019

IOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1alpha activity

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

regulation of neuron death

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

cellular iron ion homeostasis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

regulation of postsynapse organization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9

determination method

physically interacts with

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL4297619

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3544988

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3646118

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2338329

Zinc finger, MYND-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9GZT9

Oxoglutarate/iron-dependent dioxygenase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9GZT9

Prolyl 4-hydroxylase, alpha subunit

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9GZT9

Identifiers

RefSeq protein ID

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

12 April 2019

UniProt protein ID

1 reference

16 January 2019

UniProt protein ID

Ensembl protein ID

ENSP00000355601

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000355601

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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