Centromere protein E (Q21108288)

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mammalian protein found in Homo sapiens

kinesin-related protein CENPE
protein phosphatase 1, regulatory subunit 61
CENPE
kinesin-7
centromere protein E, 312kDa
centromere-associated protein E
kinesin family member 10
CENP-E
Centromere autoantigen E (312kD)

Language	Label	Description	Also known as
English	Centromere protein E	mammalian protein found in Homo sapiens	kinesin-related protein CENPE protein phosphatase 1, regulatory subunit 61 CENPE kinesin-7 centromere protein E, 312kDa centromere-associated protein E kinesin family member 10 CENP-E Centromere autoantigen E (312kD)

Statements

1 reference

13 November 2019

UniProt protein ID

kinesin motor domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02224

Kinesin-like protein

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02224

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02224

Kinesin motor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Kinesin motor domain, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

ATPase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

determination method

2 references

protein binding

determination method

5 references

8 April 2019

CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

microtubule motor activity

determination method

3 references

17 October 2017

Mitotic HeLa cells contain a CENP-E-associated minus end-directed microtubule motor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02224&geneProductId=UniProtKB:Q02224

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02224&geneProductId=UniProtKB:Q02224

determination method

17 October 2017

Mitosis. Microtubule detyrosination guides chromosomes during mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02224&geneProductId=UniProtKB:Q02224

determination method

kinetochore binding

determination method

1 reference

8 April 2019

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

microtubule motor activity

determination method

4 references

8 April 2019

Mitotic HeLa cells contain a CENP-E-associated minus end-directed microtubule motor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

Mitosis. Microtubule detyrosination guides chromosomes during mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

microtubule binding

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

Mitosis. Microtubule detyrosination guides chromosomes during mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

kinesin complex

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

determination method

1 reference

8 April 2019

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

outer kinetochore

determination method

1 reference

17 October 2017

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02224&geneProductId=UniProtKB:Q02224

determination method

chromosome, centromeric region

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

determination method

1 reference

17 October 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02224&geneProductId=UniProtKB:Q02224

determination method

determination method

determination method

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

condensed chromosome, centromeric region

determination method

1 reference

8 April 2019

A nucleolar protein RRS1 contributes to chromosome congression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

microtubule cytoskeleton

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

mitotic spindle midzone

determination method

1 reference

8 April 2019

CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

kinetochore microtubule

determination method

1 reference

8 April 2019

Mitosis. Microtubule detyrosination guides chromosomes during mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

Mitotic HeLa cells contain a CENP-E-associated minus end-directed microtubule motor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

determination method

1 reference

8 April 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

spindle midzone

determination method

1 reference

8 April 2019

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

biological process

regulation of mitotic metaphase/anaphase transition

determination method

1 reference

8 April 2019

CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

positive regulation of protein kinase activity

determination method

1 reference

8 April 2019

Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

antigen processing and presentation of exogenous peptide antigen via MHC class II

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

kinetochore assembly

determination method

1 reference

17 October 2017

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02224&geneProductId=UniProtKB:Q02224

determination method

sister chromatid cohesion

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02224&geneProductId=UniProtKB:Q02224

determination method

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

metaphase plate congression

determination method

4 references

8 April 2019

Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

Mitosis. Microtubule detyrosination guides chromosomes during mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

lateral attachment of mitotic spindle microtubules to kinetochore

determination method

1 reference

8 April 2019

Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

mitotic cell cycle

determination method

1 reference

8 April 2019

Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

mitotic spindle organization

determination method

1 reference

8 April 2019

Mitosis. Microtubule detyrosination guides chromosomes during mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

microtubule plus-end directed mitotic chromosome migration

determination method

1 reference

8 April 2019

Mitosis. Microtubule detyrosination guides chromosomes during mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

chromosome segregation

determination method

1 reference

8 April 2019

Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

mitotic metaphase plate congression

determination method

attachment of mitotic spindle microtubules to kinetochore

determination method

1 reference

8 April 2019

Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

microtubule-based movement

determination method

mitotic metaphase plate congression

determination method

3 references

8 April 2019

CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

kinetochore assembly

determination method

1 reference

8 April 2019

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02224

determination method

Kinesin motor domain, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02224

Kinesin motor domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02224

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000265148

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000265148

ENSP00000369365

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000369365

ENSP00000426023

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000426023

ENSP00000483542

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000483542

ENSP00000499964

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000499964

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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