Activation induced cytidine deaminase (Q21108149)

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mammalian protein found in Homo sapiens

single-stranded DNA cytosine deaminase
Activation-induced cytidine deaminase
cytidine aminohydrolase
AICDA
epididymis secretory protein Li 284
integrated into Burkitt's lymphoma cell line Ramos

Language	Label	Description	Also known as
English	Activation induced cytidine deaminase	mammalian protein found in Homo sapiens	single-stranded DNA cytosine deaminase Activation-induced cytidine deaminase cytidine aminohydrolase AICDA epididymis secretory protein Li 284 integrated into Burkitt's lymphoma cell line Ramos

Statements

1 reference

13 November 2019

UniProt protein ID

Cytidine deaminase-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9GZX7

Cytidine and deoxycytidylate deaminase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

APOBEC/CMP deaminase, zinc-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

determination method

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZX7&geneProductId=UniProtKB:Q9GZX7

determination method

zinc ion binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

protein binding

determination method

8 references

9 May 2019

Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

9 May 2019

CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

9 May 2019

Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

9 May 2019

PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

9 May 2019

Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

9 May 2019

TGF-β triggers HBV cccDNA degradation through AID-dependent deamination

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

9 May 2019

Active nuclear import and cytoplasmic retention of activation-induced deaminase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

9 May 2019

Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

catalytic activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

ubiquitin protein ligase binding

determination method

1 reference

9 May 2019

Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

cytidine deaminase activity

determination method

3 references

24 April 2018

Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZX7&geneProductId=UniProtKB:Q9GZX7

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZX7&geneProductId=UniProtKB:Q9GZX7

determination method

24 April 2018

Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZX7&geneProductId=UniProtKB:Q9GZX7

determination method

identical protein binding

determination method

1 reference

9 May 2019

Active nuclear import and cytoplasmic retention of activation-induced deaminase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

cytidine deaminase activity

determination method

4 references

9 May 2019

Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

9 May 2019

Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

exosome (RNase complex)

determination method

1 reference

8 April 2019

The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

determination method

4 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZX7&geneProductId=UniProtKB:Q9GZX7

determination method

24 April 2018

Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZX7&geneProductId=UniProtKB:Q9GZX7

determination method

24 April 2018

Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZX7&geneProductId=UniProtKB:Q9GZX7

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZX7&geneProductId=UniProtKB:Q9GZX7

determination method

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

9 May 2019

Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

determination method

5 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

9 May 2019

Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

9 May 2019

Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

protein-containing complex

determination method

1 reference

9 May 2019

The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

biological process

somatic hypermutation of immunoglobulin genes

determination method

1 reference

9 May 2019

Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

DNA demethylation

determination method

1 reference

24 April 2018

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZX7&geneProductId=UniProtKB:Q9GZX7

determination method

mRNA processing

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

B cell differentiation

determination method

1 reference

9 May 2019

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

somatic diversification of immunoglobulins

determination method

1 reference

9 May 2019

Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

negative regulation of DNA methylation-dependent heterochromatin assembly

determination method

1 reference

9 May 2019

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

cytidine deamination

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

cellular response to lipopolysaccharide

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

isotype switching

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

defense response to bacterium

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

regulation of DNA stability

determination method

1 reference

24 April 2018

Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZX7&geneProductId=UniProtKB:Q9GZX7

determination method

negative regulation of transposition

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

cytidine to uridine editing

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

regulation of nuclear cell cycle DNA replication

determination method

1 reference

9 May 2019

Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

defense response to virus

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

DNA cytosine deamination

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZX7

determination method

Cytidine and deoxycytidylate deaminase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9GZX7

APOBEC/CMP deaminase, zinc-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9GZX7

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000229335

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000229335

ENSP00000445691

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000445691

ENSP00000439103

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000439103

ENSP00000439538

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000439538

ENSP00000443060

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000443060

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

1 August 2016

language of work or name

Sitelinks

Wikipedia(7 entries)

dewiki Aktivierungsinduzierte Cytidin-Desaminase
enwiki Activation-induced cytidine deaminase
eswiki Deaminasa de citidina inducida por activación
huwiki AID
jawiki 活性化誘導シチジンデアミナーゼ
ukwiki AICDA
zhwiki 活化诱导性胞苷脱氨酶

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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