Calcium voltage-gated channel auxiliary subunit alpha2delta 1 (Q21105498)

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mammalian protein found in Homo sapiens

CACNA2D1
dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit
calcium channel, voltage-dependent, alpha 2/delta subunit 1
voltage-dependent calcium channel subunit alpha-2/delta-1
calcium channel, L type, alpha 2 polypeptide
voltage-gated calcium channel subunit alpha-2/delta-1

Language	Label	Description	Also known as
English	Calcium voltage-gated channel auxiliary subunit alpha2delta 1	mammalian protein found in Homo sapiens	CACNA2D1 dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit calcium channel, voltage-dependent, alpha 2/delta subunit 1 voltage-dependent calcium channel subunit alpha-2/delta-1 calcium channel, L type, alpha 2 polypeptide voltage-gated calcium channel subunit alpha-2/delta-1

Statements

1 reference

13 November 2019

UniProt protein ID

von Willebrand factor A-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54289

calcium channel auxiliary subunit alpha2delta

1 reference

based on heuristic

hierarchical database ID heuristic

VWA N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

von Willebrand factor, type A, protein family

1 reference

based on heuristic

inferred from protein domain or family

Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

voltage-gated calcium channel activity

determination method

3 references

3 January 2017

Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P54289

determination method

3 January 2017

Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P54289

determination method

3 January 2017

Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P54289

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

voltage-gated ion channel activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

calcium channel activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

voltage-gated calcium channel activity involved in cardiac muscle cell action potential

determination method

1 reference

8 April 2019

Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

voltage-gated calcium channel activity involved in bundle of His cell action potential

determination method

1 reference

8 April 2019

Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6)

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

voltage-gated calcium channel activity

determination method

5 references

8 April 2019

A β-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

8 April 2019

Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

8 April 2019

Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

8 April 2019

Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

voltage-gated calcium channel complex

determination method

L-type voltage-gated calcium channel complex

determination method

1 reference

3 January 2017

Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P54289

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

plasma membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

extracellular exosome

determination method

3 references

3 January 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P54289

determination method

3 January 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P54289

determination method

3 January 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P54289

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

sarcoplasmic reticulum

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

voltage-gated calcium channel complex

determination method

3 references

8 April 2019

Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

8 April 2019

Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

biological process

regulation of ion transmembrane transport

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

cardiac conduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

calcium ion transmembrane transport

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

calcium ion transport

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

8 April 2019

Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

8 April 2019

Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

determination method

1 reference

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P54289

determination method

cardiac muscle cell action potential involved in contraction

determination method

1 reference

8 April 2019

Functional characterization of CaVα2δ mutations associated with sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

calcium ion transport into cytosol

determination method

1 reference

8 April 2019

Functional characterization of CaVα2δ mutations associated with sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

positive regulation of high voltage-gated calcium channel activity

determination method

1 reference

8 April 2019

Functional characterization of CaVα2δ mutations associated with sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

regulation of heart rate by cardiac conduction

determination method

1 reference

8 April 2019

Functional characterization of CaVα2δ mutations associated with sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

calcium ion transmembrane transport via high voltage-gated calcium channel

determination method

1 reference

8 April 2019

Functional characterization of CaVα2δ mutations associated with sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

regulation of ventricular cardiac muscle cell membrane repolarization

determination method

1 reference

8 April 2019

Functional characterization of CaVα2δ mutations associated with sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

regulation of membrane repolarization during action potential

determination method

1 reference

8 April 2019

Functional characterization of CaVα2δ mutations associated with sudden cardiac death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

membrane depolarization during bundle of His cell action potential

determination method

1 reference

8 April 2019

Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6)

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

calcium ion import across plasma membrane

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

determination method

1 reference

8 April 2019

A β-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

cellular response to amyloid-beta

determination method

1 reference

8 April 2019

A β-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54289

determination method

physically interacts with

bepridil hydrochloride monohydrate

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200382

von Willebrand factor, type A

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54289

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54289

Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P54289

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000348589

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000348589

ENSP00000349320

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000349320

ENSP00000405395

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000405395

ENSP00000409374

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000409374

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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