SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (Q21101932)

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mammalian protein found in Homo sapiens
  • transcription activator BRG1
  • protein brahma homolog 1
  • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
  • homeotic gene regulator
  • ATP-dependent helicase SMARCA4
  • global transcription activator homologous sequence
  • brahma protein-like 1
  • BAF190A
  • SNF2-beta
  • BRM/SWI2-related gene 1
  • nuclear protein GRB1
  • SNF2-like 4
  • SMARCA4
  • sucrose nonfermenting-like 4
  • BRG1-associated factor 190A
  • mitotic growth and transcription activator
  • protein BRG-1
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Language Label Description Also known as
English
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
mammalian protein found in Homo sapiens
  • transcription activator BRG1
  • protein brahma homolog 1
  • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
  • homeotic gene regulator
  • ATP-dependent helicase SMARCA4
  • global transcription activator homologous sequence
  • brahma protein-like 1
  • BAF190A
  • SNF2-beta
  • BRM/SWI2-related gene 1
  • nuclear protein GRB1
  • SNF2-like 4
  • SMARCA4
  • sucrose nonfermenting-like 4
  • BRG1-associated factor 190A
  • mitotic growth and transcription activator
  • protein BRG-1

Statements

part of
molecular function
protein binding
determination method
IPI
28 references
retrieved
9 May 2019
stated in
BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation
GOA
curator
UniProt
UniProt protein ID
P51532
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
Heterozygous variants in ACTL6A, encoding a component of the BAF complex, are associated with intellectual disability
GOA
curator
UniProt
UniProt protein ID
P51532
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit
GOA
curator
UniProt
UniProt protein ID
P51532
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
Dual role of NRSF/REST in activation and repression of the glucocorticoid response
GOA
curator
UniProt
UniProt protein ID
P51532
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1
GOA
curator
UniProt
UniProt protein ID
P51532
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes
GOA
curator
UniProt
UniProt protein ID
P51532
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
REST repression of neuronal genes requires components of the hSWI.SNF complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
BAF60a interacts with p53 to recruit the SWI/SNF complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
Comprehensive evaluation of coding region point mutations in microsatellite‐unstable colorectal cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
Telomerase modulates Wnt signalling by association with target gene chromatin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
The role of the SWI/SNF chromatin remodeling complex in maintaining the stemness of glioma initiating cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
Selectivity of chromatin-remodelling cofactors for ligand-activated transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
Repressive LTR nucleosome positioning by the BAF complex is required for HIV latency
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
Identification of a polymorphic, neuron-specific chromatin remodeling complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
Involvement of telomerase reverse transcriptase in heterochromatin maintenance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
retrieved
9 May 2019
stated in
Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IPI
cell component
nucleus
determination method
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P51532
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IEA
retrieved
8 April 2019
stated in
Human PIH1 associates with histone H4 to mediate the glucose-dependent enhancement of pre-rRNA synthesis
GOA
curator
UniProt
UniProt protein ID
P51532
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IDA
retrieved
8 April 2019
stated in
ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1
GOA
curator
UniProt
UniProt protein ID
P51532
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IDA
retrieved
8 April 2019
stated in
Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IDA
retrieved
8 April 2019
stated in
BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IDA
nucleus
determination method
IBA
IDA
IEA
7 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P51532
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IEA
retrieved
9 May 2019
stated in
Human PIH1 associates with histone H4 to mediate the glucose-dependent enhancement of pre-rRNA synthesis
GOA
curator
UniProt
UniProt protein ID
P51532
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IDA
retrieved
9 May 2019
stated in
ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1
GOA
curator
UniProt
UniProt protein ID
P51532
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IDA
retrieved
9 May 2019
stated in
BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IDA
retrieved
9 May 2019
stated in
Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
determination method
IBA
biological process

Identifiers

RefSeq protein ID
Ensembl protein ID
 
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