protein tyrosine phosphatase non-receptor type 6 (Q21100543)

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mammalian protein found in Homo sapiens
  • protein-tyrosine phosphatase SHP-1
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6
  • SH-PTP1
  • hematopoietic cell phosphatase
  • hematopoietic cell protein-tyrosine phosphatase
  • protein-tyrosine phosphatase 1C
  • tyrosine-protein phosphatase non-receptor type 6
  • PTP-1C
  • PTPN6
edit
Language Label Description Also known as
English
protein tyrosine phosphatase non-receptor type 6
mammalian protein found in Homo sapiens
  • protein-tyrosine phosphatase SHP-1
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6
  • SH-PTP1
  • hematopoietic cell phosphatase
  • hematopoietic cell protein-tyrosine phosphatase
  • protein-tyrosine phosphatase 1C
  • tyrosine-protein phosphatase non-receptor type 6
  • PTP-1C
  • PTPN6

Statements

molecular function
protein binding
determination method
IPI
49 references
retrieved
8 April 2019
stated in
FCRL6 receptor: expression and associated proteins.
GOA
curator
UniProt
UniProt protein ID
P29350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling
GOA
curator
UniProt
UniProt protein ID
P29350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules
GOA
curator
UniProt
UniProt protein ID
P29350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development
GOA
curator
UniProt
UniProt protein ID
P29350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function
GOA
curator
UniProt
UniProt protein ID
P29350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells
GOA
curator
UniProt
UniProt protein ID
P29350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2.
GOA
curator
UniProt
UniProt protein ID
P29350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells
GOA
curator
UniProt
UniProt protein ID
P29350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70
GOA
curator
UniProt
UniProt protein ID
P29350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.
GOA
curator
UniProt
UniProt protein ID
P29350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells
GOA
curator
UniProt
UniProt protein ID
P29350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes
GOA
curator
UniProt
UniProt protein ID
P29350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor
GOA
curator
UniProt
UniProt protein ID
P29350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Identification of CD112R as a novel checkpoint for human T cells
GOA
curator
UniProt
UniProt protein ID
P29350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils
GOA
curator
UniProt
UniProt protein ID
P29350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta
GOA
curator
UniProt
UniProt protein ID
P29350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Identification of CLEC12B, an inhibitory receptor on myeloid cells.
GOA
curator
UniProt
UniProt protein ID
P29350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Molecular cloning and characterization of SPAP1, an inhibitory receptor
GOA
curator
UniProt
UniProt protein ID
P29350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Inhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: identification of potential binding sites
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
A novel phosphotyrosine motif with a critical amino acid at position -2 for the SH2 domain-mediated activation of the tyrosine phosphatase SHP-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Fine specificity and molecular competition in SLAM family receptor signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
A THEMIS:SHP1 complex promotes T-cell survival
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Thymocyte activation induces the association of the proto-oncoprotein c-cbl and ras GTPase-activating protein with CD5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Cyclophosphamide, vincristine, and the blood testis barrier
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Large-scale structural analysis of the classical human protein tyrosine phosphatome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Monitoring phosphatase reactions of multiple phosphorylated substrates by reversed-phase HPLC
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
ITIM-dependent endocytosis of CD33-related Siglecs: role of intracellular domain, tyrosine phosphorylation, and the tyrosine phosphatases, Shp1 and Shp2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: a new function for Src homology 2 domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Contribution of SHP-1 protein tyrosine phosphatase to osmotic regulation of the transcription factor TonEBP/OREBP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
The sialoadhesin CD33 is a myeloid-specific inhibitory receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
retrieved
8 April 2019
stated in
Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29350
determination method
IPI
cell component
biological process

Identifiers

MeSH descriptor ID
D053824
subject named as
Protein Tyrosine Phosphatase, Non-Receptor Type 6
1 reference
reference URL
https://meshb.nlm.nih.gov/#/record/ui?ui=D053824
 
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