Potassium inwardly rectifying channel subfamily J member 2 (Q2004050)

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mammalian protein found in Homo sapiens

potassium channel, inwardly rectifying subfamily J, member 2
cardiac inward rectifier potassium channel
Inward rectifier K(+) channel Kir2.1
Potassium channel, inwardly rectifying subfamily J member 2
IRK-1
potassium inwardly-rectifying channel, subfamily J, member 2
potassium voltage-gated channel subfamily J member 2
inward rectifier potassium channel 2
KCNJ2
hIRK1
inward rectifier K+ channel KIR2.1

Language	Label	Description	Also known as
English	Potassium inwardly rectifying channel subfamily J member 2	mammalian protein found in Homo sapiens	potassium channel, inwardly rectifying subfamily J, member 2 cardiac inward rectifier potassium channel Inward rectifier K(+) channel Kir2.1 Potassium channel, inwardly rectifying subfamily J member 2 IRK-1 potassium inwardly-rectifying channel, subfamily J, member 2 potassium voltage-gated channel subfamily J member 2 inward rectifier potassium channel 2 KCNJ2 hIRK1 inward rectifier K+ channel KIR2.1

Statements

1 reference

13 November 2019

UniProt protein ID

inward-rectifier potassium channel

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

determination method

1 reference

8 April 2019

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

voltage-gated ion channel activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

identical protein binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

phosphatidylinositol-4,5-bisphosphate binding

determination method

1 reference

8 April 2019

Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

inward rectifier potassium channel activity

determination method

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63252&geneProductId=UniProtKB:P63252

determination method

24 April 2018

Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63252&geneProductId=UniProtKB:P63252

determination method

24 April 2018

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63252&geneProductId=UniProtKB:P63252

determination method

24 April 2018

Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63252&geneProductId=UniProtKB:P63252

determination method

G-protein activated inward rectifier potassium channel activity

determination method

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63252&geneProductId=UniProtKB:P63252

determination method

inward rectifier potassium channel activity

determination method

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

8 April 2019

Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

8 April 2019

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

8 April 2019

Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

rough endoplasmic reticulum

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

Golgi apparatus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

determination method

2 references

intercalated disc

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

voltage-gated potassium channel complex

determination method

1 reference

8 April 2019

Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

dendritic spine

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

integral component of plasma membrane

determination method

1 reference

8 April 2019

Molecular cloning and expression of a human heart inward rectifier potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

smooth endoplasmic reticulum

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

neuronal cell body

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

intrinsic component of membrane

determination method

1 reference

8 April 2019

Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

biological process

cardiac muscle cell action potential

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

regulation of ion transmembrane transport

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

magnesium ion transport

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

cardiac muscle cell action potential involved in contraction

determination method

1 reference

8 April 2019

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

cellular potassium ion homeostasis

determination method

1 reference

8 April 2019

Inwardly rectifying potassium channels: their structure, function, and physiological roles

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

potassium ion transport

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

8 April 2019

Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

regulation of cardiac muscle cell contraction

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

cellular response to mechanical stimulus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

membrane repolarization during action potential

determination method

1 reference

8 April 2019

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

potassium ion transmembrane transport

determination method

1 reference

8 April 2019

Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

positive regulation of potassium ion transmembrane transport

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

regulation of skeletal muscle contraction via regulation of action potential

determination method

1 reference

8 April 2019

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

regulation of resting membrane potential

determination method

1 reference

8 April 2019

Inwardly rectifying potassium channels: their structure, function, and physiological roles

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

regulation of membrane repolarization

determination method

1 reference

8 April 2019

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

relaxation of skeletal muscle

determination method

1 reference

8 April 2019

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

regulation of heart rate by cardiac conduction

determination method

1 reference

8 April 2019

A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

membrane repolarization during cardiac muscle cell action potential

determination method

protein homotetramerization

determination method

1 reference

8 April 2019

Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

relaxation of cardiac muscle

determination method

1 reference

8 April 2019

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

membrane depolarization during cardiac muscle cell action potential

determination method

1 reference

8 April 2019

Inwardly rectifying potassium channels: their structure, function, and physiological roles

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

cardiac conduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method

Gene Atlas image

PBB GE KCNJ2 206765 at fs.png
732 × 530; 10 KB

0 references

http://purl.uniprot.org/uniprot/P63252

1 reference

Identifiers.org

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000243457

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000243457

ENSP00000441848

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000441848

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

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Multilingual sites(0 entries)

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